Life threatening biphasic adverse reactions to desmopressin: case report and review of the literature
Treatment with desmopressin diacetate arginine vasopressin (DDAVP) and its withdrawal are associated with side effects. We present a rare case of severe biphasic adverse reactions induced by DDAVP and its withdrawal in a 63-year-old female patient. A lump in the left axillary region was biopsied, an...
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| Veröffentlicht in: | International journal of clinical pharmacology and therapeutics 2016-08, Vol.54 (8), p.640-644 |
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| container_title | International journal of clinical pharmacology and therapeutics |
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| creator | Wang, Lijun Chen, Ruijun Tian, Fang Wang, Wei Wang, Li Yu, Baojun Huang, Xianwen Zhang, Yuehui Su, Shengyuan Ma, Guangnian Wang, Kaichen |
| description | Treatment with desmopressin diacetate arginine vasopressin (DDAVP) and its withdrawal are associated with side effects. We present a rare case of severe biphasic adverse reactions induced by DDAVP and its withdrawal in a 63-year-old female patient. A lump in the left axillary region was biopsied, and she received DDAVP after surgery. The following day, she lost consciousness, with foaming at the mouth and seizures. Hypotonic encephalopathy was considered. DDAVP was ceased, and she received electrolytes. On day 1, she displayed low blood pressure and increased urine output. She received DDAVP and dopamine as well as electrolytes. The patient was ambulatory on day 7 and was discharged without brain abnormalities on MRI. In conclusion, severe hyponatremia induced by DDAVP and massive polyuria and hypovolemic shock induced by DDAVP withdrawal are life-threatening conditions. This case underlines the need to be vigilant when administering DDAVP and to monitor for any side effects. |
| doi_str_mv | 10.5414/CP202461 |
| format | Article |
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We present a rare case of severe biphasic adverse reactions induced by DDAVP and its withdrawal in a 63-year-old female patient. A lump in the left axillary region was biopsied, and she received DDAVP after surgery. The following day, she lost consciousness, with foaming at the mouth and seizures. Hypotonic encephalopathy was considered. DDAVP was ceased, and she received electrolytes. On day 1, she displayed low blood pressure and increased urine output. She received DDAVP and dopamine as well as electrolytes. The patient was ambulatory on day 7 and was discharged without brain abnormalities on MRI. In conclusion, severe hyponatremia induced by DDAVP and massive polyuria and hypovolemic shock induced by DDAVP withdrawal are life-threatening conditions. This case underlines the need to be vigilant when administering DDAVP and to monitor for any side effects.</description><identifier>ISSN: 0946-1965</identifier><identifier>DOI: 10.5414/CP202461</identifier><identifier>PMID: 27142268</identifier><language>eng</language><publisher>Germany: Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG</publisher><subject>Case reports ; Deamino Arginine Vasopressin - adverse effects ; Electrolytes ; Female ; Humans ; Hyponatremia - chemically induced ; Middle Aged ; Polyuria - chemically induced ; Shock - chemically induced</subject><ispartof>International journal of clinical pharmacology and therapeutics, 2016-08, Vol.54 (8), p.640-644</ispartof><rights>Copyright Dustri - Verlag Dr. Karl Feistle GmbH & Co. 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We present a rare case of severe biphasic adverse reactions induced by DDAVP and its withdrawal in a 63-year-old female patient. A lump in the left axillary region was biopsied, and she received DDAVP after surgery. The following day, she lost consciousness, with foaming at the mouth and seizures. Hypotonic encephalopathy was considered. DDAVP was ceased, and she received electrolytes. On day 1, she displayed low blood pressure and increased urine output. She received DDAVP and dopamine as well as electrolytes. The patient was ambulatory on day 7 and was discharged without brain abnormalities on MRI. In conclusion, severe hyponatremia induced by DDAVP and massive polyuria and hypovolemic shock induced by DDAVP withdrawal are life-threatening conditions. This case underlines the need to be vigilant when administering DDAVP and to monitor for any side effects.</abstract><cop>Germany</cop><pub>Dustri - Verlag Dr. Karl Feistle GmbH & Co. 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| subjects | Case reports Deamino Arginine Vasopressin - adverse effects Electrolytes Female Humans Hyponatremia - chemically induced Middle Aged Polyuria - chemically induced Shock - chemically induced |
| title | Life threatening biphasic adverse reactions to desmopressin: case report and review of the literature |
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