Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity

Both B subunit of Shiga toxin 1 (Stx1-B), which mediates the binding of toxin to the membrane, and mutant Stx1 (mStx1), which is a non-toxic double-mutated Stx1 harboring double amino acid substitutions in the A subunit, possess potent mucosal adjuvant activity. Nasal immunization of mice with ovalb...

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Veröffentlicht in:	Vaccine 2004-09, Vol.22 (27), p.3751-3761
Hauptverfasser:	Ohmura-Hoshino, Mari, Yamamoto, Masafumi, Yuki, Yoshikazu, Takeda, Yoshifumi, Kiyono, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Animals Antigens, CD - biosynthesis Antigens, CD - immunology Applied microbiology B7-1 Antigen - biosynthesis B7-1 Antigen - immunology B7-2 Antigen Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD40 Antigens - biosynthesis CD40 Antigens - immunology Dendritic Cells - drug effects Dendritic Cells - immunology Enzyme-Linked Immunosorbent Assay Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Flow Cytometry Fundamental and applied biological sciences. Psychology Immunity, Cellular - drug effects Immunity, Mucosal - drug effects Immunization Schedule Lymphocytes - immunology Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Microbiology Mutagenesis, Site-Directed Nasopharynx - immunology Ovalbumin - immunology Shiga Toxin 1 - biosynthesis Shiga Toxin 1 - immunology Stx Up-Regulation - drug effects Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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