S-Adenosylmethionine protects against intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat

We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA 10 or 20 mg/kg per day-CyA 20 for 4 weeks) in rats. CyA treatment reduced the liver conte...

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