Determination and Pharmacokinetic Study of Pirfenidone in Rat Serum by High-Performance Thin-Layer Chromatography

A rapid, sensitive and selective high-performance thin-layer chromatography (HPTLC) method was developed and validated for the determination and pharmacokinetics of pirfenidone in rat serum. One-step protein precipitation by methanol is reported, and serum samples were separated by HPTLC using a sim...

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Veröffentlicht in:	Journal of chromatographic science 2016-08, Vol.54 (7), p.1115-1119
Hauptverfasser:	Thorat, Sonali G., Chikhale, Rupesh V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Administration, Oral Analgesics - blood Analgesics - pharmacokinetics Animals Calibration Chromatography, Thin Layer - standards Densitometry - standards Limit of Detection Male Pyridones - blood Pyridones - pharmacokinetics Rats Rats, Sprague-Dawley Reproducibility of Results Toluene
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