FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2

FK506-binding proteins 12.6 (FKBP12.6) and 12 (FKBP12) tightly associate with the cardiac ryanodine receptor (RyR2). Studies suggest that dissociation of FKBP12.6 from mutant forms of RyR2 contributes to store overload-induced Ca(2+) release (SOICR) and Ca(2+)-triggered arrhythmias. However, these f...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 2016-07, Vol.473 (14), p.2049-2060
Hauptverfasser:	Zhang, Joe Z, Waddell, Helen M M, Wu, Ella, Dholakia, Jhanvi, Okolo, Chidinma A, McLay, Janet C, Jones, Peter P
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmias, Cardiac - metabolism Calcium - metabolism HEK293 Cells Humans Ion Transport - genetics Ion Transport - physiology Mutation Protein Binding - genetics Protein Binding - physiology Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Tacrolimus Binding Protein 1A - genetics Tacrolimus Binding Protein 1A - metabolism Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!