Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation
Antiangiogenic factors are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis in vitro and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo...
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| Veröffentlicht in: | Cancer gene therapy 2004-09, Vol.11 (9), p.625-632 |
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| creator | Uesato, Masaya Gunji, Yoshio Tomonaga, Takeshi Miyazaki, Shinichi Shiratori, Tooru Matsubara, Hisahiro Kouzu, Teruo Shimada, Hideaki Nomura, Fumio Ochiai, Takenori |
| description | Antiangiogenic factors are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis
in vitro
and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo XV) delivered to tumors by low-voltage electroporation in mouse colon 26 models. A synergistic antitumor effect was strongly suggested by
in vivo
tumor growth kinetics, as well as in survival studies with the mice. RT-PCR confirmed that the fragments of each gene were transferred by low-voltage electroporation in the tumor. Decreased microvessel density measurements in tumors also confirmed the efficacy of the synergistic antitumor effect of both genes. Significant growth inhibition was observed in mice treated with a 1:1 proportion of angiostatin and endostatin genes, and the order of the both genes transferred (first the endostatin gene, followed 1 week later by the angiostatin gene) had a profound inhibitory effect on tumor growth. These data suggest that
in vivo
delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination. |
| doi_str_mv | 10.1038/sj.cgt.7700740 |
| format | Article |
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in vitro
and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo XV) delivered to tumors by low-voltage electroporation in mouse colon 26 models. A synergistic antitumor effect was strongly suggested by
in vivo
tumor growth kinetics, as well as in survival studies with the mice. RT-PCR confirmed that the fragments of each gene were transferred by low-voltage electroporation in the tumor. Decreased microvessel density measurements in tumors also confirmed the efficacy of the synergistic antitumor effect of both genes. Significant growth inhibition was observed in mice treated with a 1:1 proportion of angiostatin and endostatin genes, and the order of the both genes transferred (first the endostatin gene, followed 1 week later by the angiostatin gene) had a profound inhibitory effect on tumor growth. These data suggest that
in vivo
delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination.</description><identifier>ISSN: 0929-1903</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/sj.cgt.7700740</identifier><identifier>PMID: 15338011</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Angiogenesis ; Angiogenesis inhibitors ; Angiogenesis Inhibitors - therapeutic use ; Angiostatin ; Angiostatins - therapeutic use ; Animal models ; Animals ; Antineoplastic Agents - therapeutic use ; Antitumor activity ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Care and treatment ; Colon ; Colonic Neoplasms - drug therapy ; Dosage and administration ; Drug Synergism ; Electroporation ; Endostatin ; Endostatins - therapeutic use ; Endothelial cells ; Female ; Gene Expression ; Gene Therapy ; Genes ; Genetic aspects ; Genetic Therapy ; Health aspects ; Luciferases - metabolism ; Methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microcirculation ; Neovascularization, Pathologic ; original-article ; Polymerase chain reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Solid tumors ; Survival Rate ; Tumor Cells, Cultured ; Tumors ; Voltage</subject><ispartof>Cancer gene therapy, 2004-09, Vol.11 (9), p.625-632</ispartof><rights>Springer Nature America, Inc. 2004</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2004</rights><rights>Nature Publishing Group 2004.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-152ab686221a78a064815e497716192d7b17c54b3909863a1d4fb91f5195d8383</citedby><cites>FETCH-LOGICAL-c581t-152ab686221a78a064815e497716192d7b17c54b3909863a1d4fb91f5195d8383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.cgt.7700740$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.cgt.7700740$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15338011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uesato, Masaya</creatorcontrib><creatorcontrib>Gunji, Yoshio</creatorcontrib><creatorcontrib>Tomonaga, Takeshi</creatorcontrib><creatorcontrib>Miyazaki, Shinichi</creatorcontrib><creatorcontrib>Shiratori, Tooru</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Kouzu, Teruo</creatorcontrib><creatorcontrib>Shimada, Hideaki</creatorcontrib><creatorcontrib>Nomura, Fumio</creatorcontrib><creatorcontrib>Ochiai, Takenori</creatorcontrib><title>Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation</title><title>Cancer gene therapy</title><addtitle>Cancer Gene Ther</addtitle><addtitle>Cancer Gene Ther</addtitle><description>Antiangiogenic factors are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis
in vitro
and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo XV) delivered to tumors by low-voltage electroporation in mouse colon 26 models. A synergistic antitumor effect was strongly suggested by
in vivo
tumor growth kinetics, as well as in survival studies with the mice. RT-PCR confirmed that the fragments of each gene were transferred by low-voltage electroporation in the tumor. Decreased microvessel density measurements in tumors also confirmed the efficacy of the synergistic antitumor effect of both genes. Significant growth inhibition was observed in mice treated with a 1:1 proportion of angiostatin and endostatin genes, and the order of the both genes transferred (first the endostatin gene, followed 1 week later by the angiostatin gene) had a profound inhibitory effect on tumor growth. These data suggest that
in vivo
delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination.</description><subject>Angiogenesis</subject><subject>Angiogenesis inhibitors</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Angiostatin</subject><subject>Angiostatins - therapeutic use</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antitumor activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Colon</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Dosage and administration</subject><subject>Drug Synergism</subject><subject>Electroporation</subject><subject>Endostatin</subject><subject>Endostatins - therapeutic use</subject><subject>Endothelial cells</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Therapy</subject><subject>Health aspects</subject><subject>Luciferases - metabolism</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Microcirculation</subject><subject>Neovascularization, Pathologic</subject><subject>original-article</subject><subject>Polymerase chain reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Solid tumors</subject><subject>Survival Rate</subject><subject>Tumor Cells, 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Ther</stitle><addtitle>Cancer Gene Ther</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>11</volume><issue>9</issue><spage>625</spage><epage>632</epage><pages>625-632</pages><issn>0929-1903</issn><eissn>1476-5500</eissn><abstract>Antiangiogenic factors are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis
in vitro
and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo XV) delivered to tumors by low-voltage electroporation in mouse colon 26 models. A synergistic antitumor effect was strongly suggested by
in vivo
tumor growth kinetics, as well as in survival studies with the mice. RT-PCR confirmed that the fragments of each gene were transferred by low-voltage electroporation in the tumor. Decreased microvessel density measurements in tumors also confirmed the efficacy of the synergistic antitumor effect of both genes. Significant growth inhibition was observed in mice treated with a 1:1 proportion of angiostatin and endostatin genes, and the order of the both genes transferred (first the endostatin gene, followed 1 week later by the angiostatin gene) had a profound inhibitory effect on tumor growth. These data suggest that
in vivo
delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>15338011</pmid><doi>10.1038/sj.cgt.7700740</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer gene therapy, 2004-09, Vol.11 (9), p.625-632 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Angiogenesis Angiogenesis inhibitors Angiogenesis Inhibitors - therapeutic use Angiostatin Angiostatins - therapeutic use Animal models Animals Antineoplastic Agents - therapeutic use Antitumor activity Biomedical and Life Sciences Biomedicine Cancer Care and treatment Colon Colonic Neoplasms - drug therapy Dosage and administration Drug Synergism Electroporation Endostatin Endostatins - therapeutic use Endothelial cells Female Gene Expression Gene Therapy Genes Genetic aspects Genetic Therapy Health aspects Luciferases - metabolism Methods Mice Mice, Inbred BALB C Mice, Nude Microcirculation Neovascularization, Pathologic original-article Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction Solid tumors Survival Rate Tumor Cells, Cultured Tumors Voltage |
| title | Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation |
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