Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum

Abstract Background Morphine mediates its euphoric and analgesic effects by acting on the μ-opioid receptor (MOR). MOR belongs to the family of G-protein coupled receptors whose signaling efficiency is controlled by the regulator of G-protein signaling (RGS) proteins. Our understanding of the molecu...

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Veröffentlicht in:	Biological psychiatry (1969) 2016-08, Vol.80 (3), p.235-245
Hauptverfasser:	Sutton, Laurie P, Ostrovskaya, Olga, Dao, Maria, Xie, Keqiang, Orlandi, Cesare, Smith, Roy, Wee, Sunmee, Martemyanov, Kirill A
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals Conditioning (Psychology) Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - physiology Dopaminergic Neurons - metabolism Dopaminergic Neurons - physiology Drug Tolerance - physiology Female G Protein coupled receptors (GPCRs) Glutamic Acid - physiology Male Mice Mice, Knockout Morphine - pharmacology Neurons - physiology Nucleus Accumbens - physiology Opioids Pain Measurement - drug effects Psychiatry Regulators of G-protein signaling (RGS) Reward Reward circuit RGS Proteins - genetics RGS Proteins - metabolism RGS Proteins - physiology Self Administration Signal Transduction - drug effects Striatum Substance Withdrawal Syndrome - physiopathology
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