Lipid-based nanosystems for CD44 targeting in cancer treatment: recent significant advances, ongoing challenges and unmet needs

Extensive experimental evidence demonstrates the important role of hyaluronic acid (HA)-CD44 interaction in cell proliferation and migration, inflammation and tumor growth. Taking advantage of this interaction, the design of HA-modified nanocarriers has been investigated for targeting CD44-overexpre...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2016-07, Vol.11 (14), p.1865-1887
Hauptverfasser:	Nascimento, Thais Leite, Hillaireau, Hervé, Vergnaud, Juliette, Fattal, Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biomedical materials Cancer CD44 Cell adhesion & migration Dendritic cells Drug delivery systems Drug Delivery Systems - methods grafting density Humans Hyaluronan Receptors - metabolism hyaluronic acid Hyaluronic Acid - analogs & derivatives Hyaluronic Acid - metabolism Ligands Lipid Metabolism lipid-based nanoparticles Lipids Lipids - chemistry Liposomes - chemistry Liposomes - metabolism Metastasis Nanocapsules - chemistry Nanoparticles Neoplasms - drug therapy Neoplasms - metabolism pharmacokinetics Physiology Proteins Signal transduction toxicity trafficking pathways Tumors
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