Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity

The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species,...

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Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2016-07, Vol.311 (1), p.R157-R165
Hauptverfasser: Baris, Tara Z, Blier, Pierre U, Pichaud, Nicolas, Crawford, Douglas L, Oleksiak, Marjorie F
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container_issue 1
container_start_page R157
container_title American journal of physiology. Regulatory, integrative and comparative physiology
container_volume 311
creator Baris, Tara Z
Blier, Pierre U
Pichaud, Nicolas
Crawford, Douglas L
Oleksiak, Marjorie F
description The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species, the interactions between these two genomes can affect metabolism, growth, and fitness, depending on the environment. However, there is little data on whether these interactions impact natural populations within a single species. In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway.
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subjects Acclimatization - genetics
Acclimatization - physiology
Alleles
Animals
Body Weight
Cytochromes c - metabolism
Electron Transport Complex I - genetics
Electron Transport Complex I - metabolism
Electron Transport Complex II - genetics
Electron Transport Complex II - metabolism
Fundulidae - physiology
Gene Frequency
Gene-Environment Interaction
Genotype
Linear Models
Mitochondria - genetics
Mitochondria - metabolism
Oxidative Phosphorylation
Species Specificity
Temperature
title Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity
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