Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity
The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species,...
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Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2016-07, Vol.311 (1), p.R157-R165 |
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creator | Baris, Tara Z Blier, Pierre U Pichaud, Nicolas Crawford, Douglas L Oleksiak, Marjorie F |
description | The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species, the interactions between these two genomes can affect metabolism, growth, and fitness, depending on the environment. However, there is little data on whether these interactions impact natural populations within a single species. In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway. |
doi_str_mv | 10.1152/ajpregu.00008.2016 |
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In studies examining mitonuclear interactions among distant populations within a species or across species, the interactions between these two genomes can affect metabolism, growth, and fitness, depending on the environment. However, there is little data on whether these interactions impact natural populations within a single species. In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway.</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00008.2016</identifier><identifier>PMID: 27225945</identifier><language>eng</language><publisher>United States</publisher><subject>Acclimatization - genetics ; Acclimatization - physiology ; Alleles ; Animals ; Body Weight ; Cytochromes c - metabolism ; Electron Transport Complex I - genetics ; Electron Transport Complex I - metabolism ; Electron Transport Complex II - genetics ; Electron Transport Complex II - metabolism ; Fundulidae - physiology ; Gene Frequency ; Gene-Environment Interaction ; Genotype ; Linear Models ; Mitochondria - genetics ; Mitochondria - metabolism ; Oxidative Phosphorylation ; Species Specificity ; Temperature</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2016-07, Vol.311 (1), p.R157-R165</ispartof><rights>Copyright © 2016 the American Physiological Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-ce05c3b34d88ad345b45bca99419045c4690df9c13e6853444143f8585ae78123</citedby><cites>FETCH-LOGICAL-c347t-ce05c3b34d88ad345b45bca99419045c4690df9c13e6853444143f8585ae78123</cites><orcidid>0000-0002-6239-4012</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27225945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baris, Tara Z</creatorcontrib><creatorcontrib>Blier, Pierre U</creatorcontrib><creatorcontrib>Pichaud, Nicolas</creatorcontrib><creatorcontrib>Crawford, Douglas L</creatorcontrib><creatorcontrib>Oleksiak, Marjorie F</creatorcontrib><title>Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species, the interactions between these two genomes can affect metabolism, growth, and fitness, depending on the environment. However, there is little data on whether these interactions impact natural populations within a single species. In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway.</description><subject>Acclimatization - genetics</subject><subject>Acclimatization - physiology</subject><subject>Alleles</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Cytochromes c - metabolism</subject><subject>Electron Transport Complex I - genetics</subject><subject>Electron Transport Complex I - metabolism</subject><subject>Electron Transport Complex II - genetics</subject><subject>Electron Transport Complex II - metabolism</subject><subject>Fundulidae - physiology</subject><subject>Gene Frequency</subject><subject>Gene-Environment Interaction</subject><subject>Genotype</subject><subject>Linear Models</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>Oxidative Phosphorylation</subject><subject>Species Specificity</subject><subject>Temperature</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1OwzAURi0EoqXwAgwoI0uKf5N4RBUUpEossBI5zk3rKnGK7VTk7XFp4cpXtuTzfcNB6JbgOSGCPqjtzsF6mOM4xZxikp2hafygKeESn6MpZhlLM0LkBF15v40YZ5xdognNKRWSiyn6XIKFpBoTsHvjetuBDapNjA3glA6mtz5RTQPxaddJ_21qFcwekt2m93Hd2KoDlChbJ2EDrothD9abSJkwXqOLRrUebk73DH08P70vXtLV2_J18bhKNeN5SDVgoVnFeF0UqmZcVPFoJSUnEnOheSZx3UhNGGSFYJxzwllTiEIoyAtC2QzdH3t3rv8awIeyM15D2yoL_eBLUmCWS04Jiyg9otr13jtoyp0znXJjSXB58FqevJa_XsuD1xi6O_UPVQf1f-RPJPsBpXx28Q</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Baris, Tara Z</creator><creator>Blier, Pierre U</creator><creator>Pichaud, Nicolas</creator><creator>Crawford, Douglas L</creator><creator>Oleksiak, Marjorie F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6239-4012</orcidid></search><sort><creationdate>20160701</creationdate><title>Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity</title><author>Baris, Tara Z ; Blier, Pierre U ; Pichaud, Nicolas ; Crawford, Douglas L ; Oleksiak, Marjorie F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-ce05c3b34d88ad345b45bca99419045c4690df9c13e6853444143f8585ae78123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acclimatization - genetics</topic><topic>Acclimatization - physiology</topic><topic>Alleles</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Cytochromes c - metabolism</topic><topic>Electron Transport Complex I - genetics</topic><topic>Electron Transport Complex I - metabolism</topic><topic>Electron Transport Complex II - genetics</topic><topic>Electron Transport Complex II - metabolism</topic><topic>Fundulidae - physiology</topic><topic>Gene Frequency</topic><topic>Gene-Environment Interaction</topic><topic>Genotype</topic><topic>Linear Models</topic><topic>Mitochondria - genetics</topic><topic>Mitochondria - metabolism</topic><topic>Oxidative Phosphorylation</topic><topic>Species Specificity</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baris, Tara Z</creatorcontrib><creatorcontrib>Blier, Pierre U</creatorcontrib><creatorcontrib>Pichaud, Nicolas</creatorcontrib><creatorcontrib>Crawford, Douglas L</creatorcontrib><creatorcontrib>Oleksiak, Marjorie F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baris, Tara Z</au><au>Blier, Pierre U</au><au>Pichaud, Nicolas</au><au>Crawford, Douglas L</au><au>Oleksiak, Marjorie F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity</atitle><jtitle>American journal of physiology. 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In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway.</abstract><cop>United States</cop><pmid>27225945</pmid><doi>10.1152/ajpregu.00008.2016</doi><orcidid>https://orcid.org/0000-0002-6239-4012</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acclimatization - genetics Acclimatization - physiology Alleles Animals Body Weight Cytochromes c - metabolism Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Electron Transport Complex II - genetics Electron Transport Complex II - metabolism Fundulidae - physiology Gene Frequency Gene-Environment Interaction Genotype Linear Models Mitochondria - genetics Mitochondria - metabolism Oxidative Phosphorylation Species Specificity Temperature |
title | Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity |
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