Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption

Drug absorption is a complex process involving dissolution and precipitation, along with other kinetic processes. The purpose of this work was to (1) establish an in vitro methodology to study dissolution and precipitation in early stages of drug development where low compound consumption and high t...

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Veröffentlicht in:	Molecular pharmaceutics 2016-02, Vol.13 (2), p.586-598
Hauptverfasser:	Jakubiak, Paulina, Wagner, Björn, Grimm, Hans Peter, Petrig-Schaffland, Jeannine, Schuler, Franz, Alvarez-Sánchez, Rubén
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Computer Simulation Erlotinib Hydrochloride - administration & dosage Erlotinib Hydrochloride - pharmacokinetics Gastrointestinal Absorption - drug effects Humans Kinetics Models, Biological Permeability - drug effects Tissue Distribution
Online-Zugang:	Volltext
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