Importance of the Direct Contact of Amorphous Solid Particles with the Surface of Monolayers for the Transepithelial Permeation of Curcumin

The amorphization has been generally known to improve the absorption and permeation of poorly water-soluble drugs through the enhancement of the solubility. The present study focused on the direct contact of amorphous solid particles with the surface of the membrane using curcumin as a model for wat...

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Veröffentlicht in:	Molecular pharmaceutics 2016-02, Vol.13 (2), p.493-499
Hauptverfasser:	Kimura, Shunsuke, Kasatani, Sachiha, Tanaka, Megumi, Araki, Kaeko, Enomura, Masakazu, Moriyama, Kei, Inoue, Daisuke, Furubayashi, Tomoyuki, Tanaka, Akiko, Kusamori, Kosuke, Katsumi, Hidemasa, Sakane, Toshiyasu, Yamamoto, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Membrane Permeability - drug effects Chemistry, Pharmaceutical Curcumin - chemistry Curcumin - pharmacology Dogs Epithelial Cells - drug effects Madin Darby Canine Kidney Cells Nanoparticles - chemistry Solubility Suspensions Water
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