Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant?

Drug transporters are becoming increasingly recognized as relevant to the drug development process. This may be a reflection of increasing target complexity and the need for high‐affinity interaction with drug targets that minimize off‐target side effects. Moreover, as new molecular entities (NMEs)...

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Veröffentlicht in:	Journal of clinical pharmacology 2016-07, Vol.56 (S7), p.S40-S58
Hauptverfasser:	McLean, Cheynne, Wilson, Aze, Kim, Richard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Sub-Family B - genetics ATP Binding Cassette Transporter, Sub-Family B - metabolism drug development Drug Discovery - methods Drug Discovery - trends Drug Interactions - physiology drug transporters Humans Liver - drug effects Liver - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Pharmaceutical industry Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - metabolism pharmacogenomics Polymorphism, Genetic - physiology
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