The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation

Epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein expressed on adenomatous and simple epithelia, where it is involved in homophilic adhesion at the basolateral membrane. Carcinomas strongly overexpress EpCAM through an, as yet, unknown mechanism. Interestingly, otherwise EpCAM-neg...

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Veröffentlicht in:	Oncogene 2004-07, Vol.23 (34), p.5748-5758
Hauptverfasser:	Münz, Markus, Kieu, Cuong, Mack, Brigitte, Schmitt, Bärbel, Zeidler, Reinhard, Gires, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - metabolism 3T3 Cells - pathology Amino acids Animals Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Antisense RNA Apoptosis Biological and medical sciences c-Myc protein Cancer Carcinogenesis Carcinogenicity Tests Carcinoma Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Biology Cell cycle Cell Cycle - physiology Cell Division - physiology Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cooperation Cyclin A Cyclin A - genetics Cyclin A - metabolism Cyclin E - genetics Cyclin E - metabolism Dysplasia Epithelial Cell Adhesion Molecule Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Fibroblasts Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Growth factors Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metabolism Mice Molecular and cellular biology mRNA Myc protein Oncology original-paper Otolaryngology Protein Structure, Tertiary Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Up-Regulation
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