Role of CYP3A enzymes in the biotransformation of triazolam in rat liver

1. Triazolam (TRZ) has been used extensively in rat to evaluate its benzodiazepine agonist central nervous system effects. However, the pharmacokinetics of TRZ in the male rat are not well understood. 2. To characterize further TRZ biotransformation across species, the NADPH-dependent biotransformat...

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Veröffentlicht in:	Xenobiotica 2004-05, Vol.34 (5), p.463-471
Hauptverfasser:	Warrington, J. S., Greenblatt, D. J., Von Moltke, L. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - metabolism Biotransformation Cytochrome P-450 CYP3A Enzyme Inhibitors - pharmacology GABA-A Receptor Agonists Humans Hydroxylation In Vitro Techniques Isoenzymes - metabolism Ketoconazole - pharmacology Kinetics Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Oxidoreductases, N-Demethylating - antagonists & inhibitors Oxidoreductases, N-Demethylating - metabolism Rats Rats, Inbred F344 Recombinant Proteins - metabolism Triazolam - metabolism
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