Use of DNA from Human Stools to Detect Aberrant CpG Island Methylation of Genes Implicated in Colorectal Cancer

Hypermethylation of cytosine residues in the CpG islands of tumor suppressor genes is a key mechanism of colorectal carcinogenesis. Detection and quantification of CpG island methylation in human DNA isolated from stools might provide a novel strategy for the detection and investigation of colorecta...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-09, Vol.13 (9), p.1495-1501
Hauptverfasser:	BELSHAW, Nigel J, ELLIOTT, Giles O, WILLIAMS, Elizabeth A, BRADBURN, David M, MILLS, Sarah J, MATHERS, John C, JOHNSON, Ian T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyps - diagnosis Adenomatous Polyps - genetics Adenomatous Polyps - pathology Alleles Biological and medical sciences Biopsy Case-Control Studies Colectomy Colonoscopy Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology CpG Islands - genetics DNA Methylation DNA Primers - genetics Epigenesis, Genetic Feasibility Studies Feces - chemistry Female Gastroenterology. Liver. Pancreas. Abdomen Genes, Tumor Suppressor Humans Intestinal Mucosa - pathology Male Mass Screening Medical sciences Middle Aged Polymerase Chain Reaction Risk Assessment Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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