GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion

Significance Autophagy is an essential homeostatic process that is critically important for maintaining health and that is dysregulated in multiple devastating diseases. The steps in the final stages of autophagy that culminate in autophagosome:lysosome fusion are not well understood. The γ-aminobut...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-06, Vol.112 (22), p.7015-7020
Hauptverfasser:	Wang, Hanzhi, Sun, Hui-Qiao, Zhu, Xiaohui, Zhang, Li, Albanesi, Joseph, Levine, Beth, Yin, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	1-phosphatidylinositol 4-kinase Adaptor Proteins, Signal Transducing - metabolism autophagy Biological Sciences Biosynthesis Cell Fusion Cells Fusion gamma-aminobutyric acid Gene expression HeLa Cells Humans Immunoprecipitation lipids lysosomes Lysosomes - metabolism mammals Maturation Membranes Microscopy, Confocal Microscopy, Electron Microtubule-Associated Proteins - metabolism Minor Histocompatibility Antigens Phagosomes - metabolism Phosphatidylinositol Phosphates - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Proteins RNA, Small Interfering - genetics
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