Specialized stem cell niche enables repetitive renewal of alligator teeth

Reptiles and fish have robust regenerative powers for tooth renewal. However, extant mammals can either renew their teeth one time (diphyodont dentition) or not at all (monophyodont dentition). Humans replace their milk teeth with permanent teeth and then lose their ability for tooth renewal. Here,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (22), p.E2009-E2018
Hauptverfasser:	Wu, Ping, Wu, Xiaoshan, Jiang, Ting-Xin, Elsey, Ruth M, Temple, Bradley L, Divers, Stephen J, Glenn, Travis C, Yuan, Kuo, Chen, Min-Huey, Widelitz, Randall B, Chuong, Cheng-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	adults alligators Alligators and Crocodiles Animals beta Catenin - metabolism Biological Sciences Bromodeoxyuridine cell adhesion Cell adhesion & migration Cell Proliferation Correlation analysis fish Glycoproteins - metabolism humans In Situ Hybridization Intracellular Signaling Peptides and Proteins milk Models, Animal Models, Biological Molecules Odontogenesis - physiology PNAS Plus Regeneration - physiology Reptiles & amphibians Signal Transduction - physiology Stem cells Stem Cells - physiology Teeth Tenascin - metabolism Tooth - cytology Tooth - physiology X-Ray Microtomography
Online-Zugang:	Volltext
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