Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy

The clinical severity of the neurodegenerative disorder spinal muscular atrophy (SMA) is dependent on the levels of functional Survival Motor Neuron (SMN) protein. Consequently, current strategies for developing treatments for SMA generally focus on augmenting SMN levels. To identify additional pote...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (26), p.E2371-E2380
Hauptverfasser:	Sen, Anindya, Dimlich, Douglas N, Guruharsha, K G, Kankel, Mark W, Hori, Kazuya, Yokokura, Takakazu, Brachat, Sophie, Richardson, Delwood, Loureiro, Joseph, Sivasankaran, Rajeev, Curtis, Daniel, Davidow, Lance S, Rubin, Lee L, Hart, Anne C, Van Vactor, David, Artavanis-Tsakonas, Spyros
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biochemistry bioinformatics Biological Sciences Drosophila Drosophila Proteins - genetics Gene Regulatory Networks genes Genes, Insect Genetics Genotype & phenotype Humans Insects Knowledge Bases motor neurons muscular atrophy neurodegenerative diseases Neuromuscular Junction - genetics Phenotype PNAS Plus Proteins RNA Interference RNA-Binding Proteins - genetics Species Specificity Spinal Muscular Atrophies of Childhood - genetics
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