Chloride binding site of neurotransmitter sodium symporters

Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue (Glu290 in LeuT) at a site where eukaryotic NSSs hav...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (21), p.8489-8494
Hauptverfasser:	Kantcheva, Adriana K., Quick, Matthias, Shi, Lei, Winther, Anne-Marie Lund, Stolzenberg, Sebastian, Weinstein, Harel, Javitch, Jonathan A., Nissen, Poul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anions Bacteria - chemistry Bacteria - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Biological Sciences Bromides - chemistry Bromides - metabolism Chlorides Chlorides - chemistry Chlorides - metabolism Crystal structure Crystallography, X-Ray Ions molecular dynamics Molecules mutants Neurotransmitters Plasma Membrane Neurotransmitter Transport Proteins - chemistry Plasma Membrane Neurotransmitter Transport Proteins - metabolism Prokaryotes serine Serotonin plasma membrane transport proteins Simulation Sodium Symporters
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!