Histone deacetylase 10 promotes autophagy-mediated cell survival

Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro and in vivo evidence that histone deacetylase (HDAC)10 promotes autophagy-mediated survival in neuroblastoma cells. We show that both knockdown...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (28), p.E2592-E2601
Hauptverfasser:	Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C, Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H, Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R, Deubzer, Hedwig E, Witt, Olaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Autophagy - physiology Biological Sciences Cell Line, Tumor Cell Survival - physiology cell viability cytotoxicity DNA damage doxorubicin drug therapy Gene expression Heat shock proteins heat-shock protein 70 histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histone Deacetylases - physiology HSP70 Heat-Shock Proteins - metabolism Humans isozymes lysosomes neoplasm cells neoplasms Neuroblastoma - enzymology Neuroblastoma - pathology oncogenes patients PNAS Plus Protein Binding Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Stress response Survival analysis Tumors
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