Human and Helicobacter pylori coevolution shapes the risk of gastric disease

Helicobacter pylori is the principal cause of gastric cancer, the second leading cause of cancer mortality worldwide. However, H. pylori prevalence generally does not predict cancer incidence. To determine whether coevolution between host and pathogen influences disease risk, we examined the associa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-01, Vol.111 (4), p.1455-1460
Hauptverfasser:	Kodaman, Nuri, Pazos, Alvaro, Schneider, Barbara G., Piazuelo, M. Blanca, Mera, Robertino, Sobota, Rafal S., Sicinschi, Liviu A., Shaffer, Carrie L., Romero-Gallo, Judith, de Sablet, Thibaut, Harder, Reed H., Bravo, Luis E., Peek, Richard M., Wilson, Keith T., Cover, Timothy L., Williams, Scott M., Correa, Pelayo
Format:	Artikel
Sprache:	eng
Schlagworte:	Admixtures Adult Aged Ancestry Biological Sciences coasts coevolution Colombia Disease Susceptibility Evolution, Molecular Gastric cancer Gastrointestinal diseases genetic variation genome Genomes geography Gram-negative bacteria Helicobacter Infections - complications Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Human genetics Humans Infections Lesions Middle Aged Modeling mortality Pathogens patients risk Risk factors Social interaction Stomach Diseases - microbiology stomach neoplasms
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