Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion
Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone...
Gespeichert in:
| Veröffentlicht in: | Behavioural brain research 2004-08, Vol.153 (1), p.61-67 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 67 |
|---|---|
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Behavioural brain research |
| container_volume | 153 |
| creator | Sanchis-Segura, Carles Pastor, Raúl Aragon, Carlos M.G |
| description | Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone doses (0.001–1.000
mg/kg) on the locomotor changes produced by ethanol (2.5
g/kg) were evaluated. In a second set of experiments, the ability of repeated naltrexone (6
mg/kg) administrations to modify the effects of ethanol was also assessed on mice locomotion. The results of the present study revealed that an acute naltrexone administration reduced dose-dependently ethanol-induced locomotion. Conversely, after repeated naltrexone injections, a transient boost of ethanol induced locomotor activity was observed. Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity. Moreover, the same (acute and chronic) naltrexone pretreatments produced similar changes on the locomotion of mice after a challenge with morphine (a MOR agonist), but not after
tert-butanol (an alcohol which does not release β-endorphins) administration. Therefore, our results are discussed in terms of the proved ability of ethanol to promote the release of β-endorphins and, consequently, to activate the MOR. |
| doi_str_mv | 10.1016/j.bbr.2003.11.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18029354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166432803004236</els_id><sourcerecordid>18029354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-531abfbbbcf2a819d019bba46ec3d98569e602762327340539023b15c4d3cb803</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AC_Si95aM0m_gicRv0DwoueYpFPM0iZr0or-e7Psgp6EgRcmzwyTh5BToAVQqC-XhdahYJTyAqBIsUMW0DYsb6pS7JJFYuq85Kw9IIcxLimlJa1gnxxAxUA0tFmQt-fVykc7YYZ9j2aKme8zZebU-MQQ55iZ9-CdNZlTwxTwyzvMVDdaZ-MU1GS9y1Lh9K6cH3Lrutlglw3e-NGvX4_JXq-GiCfbPCKvd7cvNw_50_P94831U25KoFNecVC611qbnqkWREdBaK3KGg3vRFvVAmvKmppx1vD0Cy4o4xoqU3bc6JbyI3Kx2bsK_mPGOMnRRoPDoBz6OUpoKRO8KhMIG9AEH2PAXq6CHVX4lkDlWqtcyqRVrrVKAJkizZxtl896xO53YusxAedbQEWjhj4oZ2z8w4mStWLNXW04TCo-LQYZjUWXlNmQ7MvO23_O-AEsj5ZB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18029354</pqid></control><display><type>article</type><title>Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sanchis-Segura, Carles ; Pastor, Raúl ; Aragon, Carlos M.G</creator><creatorcontrib>Sanchis-Segura, Carles ; Pastor, Raúl ; Aragon, Carlos M.G</creatorcontrib><description>Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone doses (0.001–1.000
mg/kg) on the locomotor changes produced by ethanol (2.5
g/kg) were evaluated. In a second set of experiments, the ability of repeated naltrexone (6
mg/kg) administrations to modify the effects of ethanol was also assessed on mice locomotion. The results of the present study revealed that an acute naltrexone administration reduced dose-dependently ethanol-induced locomotion. Conversely, after repeated naltrexone injections, a transient boost of ethanol induced locomotor activity was observed. Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity. Moreover, the same (acute and chronic) naltrexone pretreatments produced similar changes on the locomotion of mice after a challenge with morphine (a MOR agonist), but not after
tert-butanol (an alcohol which does not release β-endorphins) administration. Therefore, our results are discussed in terms of the proved ability of ethanol to promote the release of β-endorphins and, consequently, to activate the MOR.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2003.11.003</identifier><identifier>PMID: 15219707</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Central Nervous System Depressants - pharmacology ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Interactions ; Ethanol ; Ethanol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Locomotion ; Mice ; Motor Activity - drug effects ; Mu opioid receptor (MOR) ; Naltrexone ; Naltrexone - administration & dosage ; Narcotic Antagonists - administration & dosage ; Neurotransmission and behavior ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; β-endorphin</subject><ispartof>Behavioural brain research, 2004-08, Vol.153 (1), p.61-67</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-531abfbbbcf2a819d019bba46ec3d98569e602762327340539023b15c4d3cb803</citedby><cites>FETCH-LOGICAL-c410t-531abfbbbcf2a819d019bba46ec3d98569e602762327340539023b15c4d3cb803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432803004236$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15942897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15219707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanchis-Segura, Carles</creatorcontrib><creatorcontrib>Pastor, Raúl</creatorcontrib><creatorcontrib>Aragon, Carlos M.G</creatorcontrib><title>Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone doses (0.001–1.000
mg/kg) on the locomotor changes produced by ethanol (2.5
g/kg) were evaluated. In a second set of experiments, the ability of repeated naltrexone (6
mg/kg) administrations to modify the effects of ethanol was also assessed on mice locomotion. The results of the present study revealed that an acute naltrexone administration reduced dose-dependently ethanol-induced locomotion. Conversely, after repeated naltrexone injections, a transient boost of ethanol induced locomotor activity was observed. Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity. Moreover, the same (acute and chronic) naltrexone pretreatments produced similar changes on the locomotion of mice after a challenge with morphine (a MOR agonist), but not after
tert-butanol (an alcohol which does not release β-endorphins) administration. Therefore, our results are discussed in terms of the proved ability of ethanol to promote the release of β-endorphins and, consequently, to activate the MOR.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug Interactions</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Locomotion</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Mu opioid receptor (MOR)</subject><subject>Naltrexone</subject><subject>Naltrexone - administration & dosage</subject><subject>Narcotic Antagonists - administration & dosage</subject><subject>Neurotransmission and behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>β-endorphin</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AC_Si95aM0m_gicRv0DwoueYpFPM0iZr0or-e7Psgp6EgRcmzwyTh5BToAVQqC-XhdahYJTyAqBIsUMW0DYsb6pS7JJFYuq85Kw9IIcxLimlJa1gnxxAxUA0tFmQt-fVykc7YYZ9j2aKme8zZebU-MQQ55iZ9-CdNZlTwxTwyzvMVDdaZ-MU1GS9y1Lh9K6cH3Lrutlglw3e-NGvX4_JXq-GiCfbPCKvd7cvNw_50_P94831U25KoFNecVC611qbnqkWREdBaK3KGg3vRFvVAmvKmppx1vD0Cy4o4xoqU3bc6JbyI3Kx2bsK_mPGOMnRRoPDoBz6OUpoKRO8KhMIG9AEH2PAXq6CHVX4lkDlWqtcyqRVrrVKAJkizZxtl896xO53YusxAedbQEWjhj4oZ2z8w4mStWLNXW04TCo-LQYZjUWXlNmQ7MvO23_O-AEsj5ZB</recordid><startdate>20040812</startdate><enddate>20040812</enddate><creator>Sanchis-Segura, Carles</creator><creator>Pastor, Raúl</creator><creator>Aragon, Carlos M.G</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20040812</creationdate><title>Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion</title><author>Sanchis-Segura, Carles ; Pastor, Raúl ; Aragon, Carlos M.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-531abfbbbcf2a819d019bba46ec3d98569e602762327340539023b15c4d3cb803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug Interactions</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Locomotion</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Mu opioid receptor (MOR)</topic><topic>Naltrexone</topic><topic>Naltrexone - administration & dosage</topic><topic>Narcotic Antagonists - administration & dosage</topic><topic>Neurotransmission and behavior</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>β-endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanchis-Segura, Carles</creatorcontrib><creatorcontrib>Pastor, Raúl</creatorcontrib><creatorcontrib>Aragon, Carlos M.G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanchis-Segura, Carles</au><au>Pastor, Raúl</au><au>Aragon, Carlos M.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2004-08-12</date><risdate>2004</risdate><volume>153</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone doses (0.001–1.000
mg/kg) on the locomotor changes produced by ethanol (2.5
g/kg) were evaluated. In a second set of experiments, the ability of repeated naltrexone (6
mg/kg) administrations to modify the effects of ethanol was also assessed on mice locomotion. The results of the present study revealed that an acute naltrexone administration reduced dose-dependently ethanol-induced locomotion. Conversely, after repeated naltrexone injections, a transient boost of ethanol induced locomotor activity was observed. Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity. Moreover, the same (acute and chronic) naltrexone pretreatments produced similar changes on the locomotion of mice after a challenge with morphine (a MOR agonist), but not after
tert-butanol (an alcohol which does not release β-endorphins) administration. Therefore, our results are discussed in terms of the proved ability of ethanol to promote the release of β-endorphins and, consequently, to activate the MOR.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>15219707</pmid><doi>10.1016/j.bbr.2003.11.003</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2004-08, Vol.153 (1), p.61-67 |
| issn | 0166-4328 1872-7549 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18029354 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Central Nervous System Depressants - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Drug Interactions Ethanol Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Locomotion Mice Motor Activity - drug effects Mu opioid receptor (MOR) Naltrexone Naltrexone - administration & dosage Narcotic Antagonists - administration & dosage Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology β-endorphin |
| title | Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A05%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Opposite%20effects%20of%20acute%20versus%20chronic%20naltrexone%20administration%20on%20ethanol-induced%20locomotion&rft.jtitle=Behavioural%20brain%20research&rft.au=Sanchis-Segura,%20Carles&rft.date=2004-08-12&rft.volume=153&rft.issue=1&rft.spage=61&rft.epage=67&rft.pages=61-67&rft.issn=0166-4328&rft.eissn=1872-7549&rft.coden=BBREDI&rft_id=info:doi/10.1016/j.bbr.2003.11.003&rft_dat=%3Cproquest_cross%3E18029354%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18029354&rft_id=info:pmid/15219707&rft_els_id=S0166432803004236&rfr_iscdi=true |