Peptide Inhibitors of Hepatitis C Virus NS3 Protease

Hepatitis C virus (HCV) is a highly prevalent virus and one of the major agents of chronic hepatitis. Since HCV NS3 protease is essential for the processing of HCV polyprotein, this protease is a target of choice to control HCV replication. Peptide inhibitors of NS3 were developed by selective amino...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2003-10, Vol.14 (5), p.225-233
Hauptverfasser:	Portal-Núñez, Sergio, González-Navarro, Carlos J, García-Delgado, Marina, Vizmanos, José Luis, Lasarte, Juan José, Borrás-Cuesta, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Fluorescent indicators Hepatitis Hepatitis C Hepatitis C - drug therapy Hepatitis C virus Humans Hydrolysis Inhibitory Concentration 50 Interferon Kinetics Medical sciences Molecular Mimicry NS4A protein Oligopeptides - chemistry Oligopeptides - pharmacology Peptide inhibitors Peptides Peptidomimetics Pharmacology. Drug treatments Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Protein sorting signals Proteinase Replication Structure-Activity Relationship Viral Nonstructural Proteins - antagonists & inhibitors
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