Inhibition of TATA Binding Protein Dimerization by RNA Polymerase III Transcription Initiation Factor Brf1

The Brf1 subunit of TFIIIB plays an important role in recruiting the TATA-binding protein (TBP) to the up-stream region of genes transcribed by RNA polymerase III. When TBP is not bound to promoters, it sequesters its DNA binding domain through dimerization. Promoter assembly factors therefore might...

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Veröffentlicht in:	The Journal of biological chemistry 2004-07, Vol.279 (31), p.32401-32406
Hauptverfasser:	Alexander, Diane E, Kaczorowski, David J, Jackson-Fisher, Amy J, Lowery, Drew M, Zanton, Sara J, Pugh, B Franklin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Cross-Linking Reagents - pharmacology Dimerization Gene Deletion Glutathione Transferase - metabolism Humans Models, Biological Mutation Plasmids - metabolism Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Recombinant Proteins - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA Polymerase III - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins TATA-Binding Protein Associated Factors TATA-Box Binding Protein - chemistry Time Factors Transcription Factor TFIIIB - chemistry Transcription Factor TFIIIB - metabolism Transcription, Genetic
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