Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains

Abdul Rehman and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved throughout eukaryotes and show a remarkable selectivity for cleaving extended Lys-48-linked polyubiquitin chains. Abdul Rehman and colleagues identify a sixth family of deubiquitinase enzymes that...

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Veröffentlicht in:Molecular cell 2016-07, Vol.63 (1), p.4-6
Hauptverfasser: Maurer, Till, Wertz, Ingrid E.
Format: Artikel
Sprache:eng
Schlagworte:
Deubiquitinating Enzymes
Eukaryota
Humans
Polyubiquitin
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Zusammenfassung:Abdul Rehman and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved throughout eukaryotes and show a remarkable selectivity for cleaving extended Lys-48-linked polyubiquitin chains. Abdul Rehman and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved throughout eukaryotes and show a remarkable selectivity for cleaving extended Lys-48-linked polyubiquitin chains.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2016.06.027