Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

The signal recognition particle (SRP) is a ribonucleoprotein complex with a key role in targeting and insertion of membrane proteins. The two SRP GTPases, SRP54 (Ffh in bacteria) and FtsY (SRα in eukaryotes), form the core of the targeting complex (TC) regulating the SRP cycle. The architecture of t...

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Veröffentlicht in:	Journal of molecular biology 2016-07, Vol.428 (14), p.2880-2897
Hauptverfasser:	Wild, Klemens, Bange, Gert, Motiejunas, Domantas, Kribelbauer, Judith, Hendricks, Astrid, Segnitz, Bernd, Wade, Rebecca C., Sinning, Irmgard
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites - physiology co-translational protein targeting Dimerization GTP Phosphohydrolases - chemistry GTP Phosphohydrolases - metabolism Humans Molecular Dynamics Simulation molecular modeling Protein Binding - physiology Protein Structure, Tertiary ribonucleoprotein complex Signal Recognition Particle - chemistry Signal Recognition Particle - metabolism SRP GTPase Sulfolobus solfataricus - metabolism X-ray structure analysis
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