Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To monitor such treatments, fluid biomarkers reflecting the underlying disease process are crucial. We found robust incre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-07, Vol.91 (1), p.56-66
Hauptverfasser:	Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Age alpha-Synuclein - metabolism Alzheimer's disease Animals Axons - metabolism Biomarkers Biomarkers - blood Biomarkers - cerebrospinal fluid Brain - metabolism Brain - pathology Brain research Confidence intervals Dementia Disease Progression Intermediate Filaments - metabolism Mice, Inbred C57BL Mice, Transgenic Neurodegeneration Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurofilament Proteins - blood Neurofilament Proteins - cerebrospinal fluid Pathology Plasma Rodents Scholarships & fellowships Software Statistical analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!