HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes
Maternal glucose and weight gain are related to neonatal outcome in women with gestational diabetes mellitus (GDM). The aim of this study was to explore the influence of average third-trimester HbA1c and excess gestational weight gain on GDM neonatal complications. This observational study included...
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| Veröffentlicht in: | Journal of women's health (Larchmont, N.Y. 2002) N.Y. 2002), 2016-06, Vol.25 (6), p.579-585 |
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| container_title | Journal of women's health (Larchmont, N.Y. 2002) |
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| creator | Barquiel, Beatriz Herranz, Lucrecia Hillman, Natalia Burgos, Ma Ángeles Grande, Cristina Tukia, Keleni M Bartha, José Luis Pallardo, Luis Felipe |
| description | Maternal glucose and weight gain are related to neonatal outcome in women with gestational diabetes mellitus (GDM). The aim of this study was to explore the influence of average third-trimester HbA1c and excess gestational weight gain on GDM neonatal complications.
This observational study included 2037 Spanish singleton pregnant women with GDM followed in our Diabetes and Pregnancy Unit. The maternal HbA1c level was measured monthly from GDM diagnosis to delivery. Women were compared by average HbA1c level and weight gain categorized into ≤ or > the current Institute of Medicine (IOM) recommendations for body mass index. The differential effects of these factors on large-for-gestational-age birth weight and a composite of neonatal complications were assessed.
Women with an average third-trimester HbA1c ≥5.0% (n = 1319) gave birth to 7.3% versus 3.8% (p = 0.005) of large-for-gestational-age neonates and 22.0% versus 16.0% (p = 0.006) of neonates with complications. Women with excess gestational weight gain (n = 299) delivered 12.5% versus 5.2% (p |
| doi_str_mv | 10.1089/jwh.2015.5432 |
| format | Article |
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This observational study included 2037 Spanish singleton pregnant women with GDM followed in our Diabetes and Pregnancy Unit. The maternal HbA1c level was measured monthly from GDM diagnosis to delivery. Women were compared by average HbA1c level and weight gain categorized into ≤ or > the current Institute of Medicine (IOM) recommendations for body mass index. The differential effects of these factors on large-for-gestational-age birth weight and a composite of neonatal complications were assessed.
Women with an average third-trimester HbA1c ≥5.0% (n = 1319) gave birth to 7.3% versus 3.8% (p = 0.005) of large-for-gestational-age neonates and 22.0% versus 16.0% (p = 0.006) of neonates with complications. Women with excess gestational weight gain (n = 299) delivered 12.5% versus 5.2% (p < 0.001) of large-for-gestational-age neonates and 24.7% versus 19.0% (p = 0.022) of neonates with complications. In an adjusted multiple logistic regression analysis among mothers exposed to the respective risk factors, ∼47% and 52% of large-for-gestational-age neonates and 32% and 37% of neonatal complications were potentially preventable by attaining an average third-trimester HbA1c level <5.0% and optimizing gestational weight gain.
Average third-trimester HbA1c level ≥5% and gestational weight gain above the IOM recommendation are relevant risk factors for neonatal complications in mothers with gestational diabetes.</description><identifier>ISSN: 1540-9996</identifier><identifier>EISSN: 1931-843X</identifier><identifier>DOI: 10.1089/jwh.2015.5432</identifier><identifier>PMID: 26918922</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Birth Weight ; Blood Glucose - metabolism ; Body Mass Index ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes, Gestational - blood ; Diabetes, Gestational - ethnology ; Female ; Fetal Macrosomia - ethnology ; Fetal Macrosomia - etiology ; Gestational Age ; Glycated Hemoglobin A - metabolism ; Hispanic Americans - statistics & numerical data ; Humans ; Infant, Newborn ; Mothers ; Obesity - complications ; Obesity - epidemiology ; Postprandial Period ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy in Diabetics - blood ; Pregnancy in Diabetics - ethnology ; Pregnancy Trimester, Third ; Retrospective Studies ; Risk Factors ; Socioeconomic Factors ; United States ; Weight Gain</subject><ispartof>Journal of women's health (Larchmont, N.Y. 2002), 2016-06, Vol.25 (6), p.579-585</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-f395f66880d62bc765353471b44fef7ae7dfbecffd7cdeb9c6d6c196c734678c3</citedby><cites>FETCH-LOGICAL-c326t-f395f66880d62bc765353471b44fef7ae7dfbecffd7cdeb9c6d6c196c734678c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26918922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barquiel, Beatriz</creatorcontrib><creatorcontrib>Herranz, Lucrecia</creatorcontrib><creatorcontrib>Hillman, Natalia</creatorcontrib><creatorcontrib>Burgos, Ma Ángeles</creatorcontrib><creatorcontrib>Grande, Cristina</creatorcontrib><creatorcontrib>Tukia, Keleni M</creatorcontrib><creatorcontrib>Bartha, José Luis</creatorcontrib><creatorcontrib>Pallardo, Luis Felipe</creatorcontrib><title>HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes</title><title>Journal of women's health (Larchmont, N.Y. 2002)</title><addtitle>J Womens Health (Larchmt)</addtitle><description>Maternal glucose and weight gain are related to neonatal outcome in women with gestational diabetes mellitus (GDM). The aim of this study was to explore the influence of average third-trimester HbA1c and excess gestational weight gain on GDM neonatal complications.
This observational study included 2037 Spanish singleton pregnant women with GDM followed in our Diabetes and Pregnancy Unit. The maternal HbA1c level was measured monthly from GDM diagnosis to delivery. Women were compared by average HbA1c level and weight gain categorized into ≤ or > the current Institute of Medicine (IOM) recommendations for body mass index. The differential effects of these factors on large-for-gestational-age birth weight and a composite of neonatal complications were assessed.
Women with an average third-trimester HbA1c ≥5.0% (n = 1319) gave birth to 7.3% versus 3.8% (p = 0.005) of large-for-gestational-age neonates and 22.0% versus 16.0% (p = 0.006) of neonates with complications. Women with excess gestational weight gain (n = 299) delivered 12.5% versus 5.2% (p < 0.001) of large-for-gestational-age neonates and 24.7% versus 19.0% (p = 0.022) of neonates with complications. In an adjusted multiple logistic regression analysis among mothers exposed to the respective risk factors, ∼47% and 52% of large-for-gestational-age neonates and 32% and 37% of neonatal complications were potentially preventable by attaining an average third-trimester HbA1c level <5.0% and optimizing gestational weight gain.
Average third-trimester HbA1c level ≥5% and gestational weight gain above the IOM recommendation are relevant risk factors for neonatal complications in mothers with gestational diabetes.</description><subject>Adult</subject><subject>Birth Weight</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - ethnology</subject><subject>Female</subject><subject>Fetal Macrosomia - ethnology</subject><subject>Fetal Macrosomia - etiology</subject><subject>Gestational Age</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hispanic Americans - statistics & numerical data</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Mothers</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Postprandial Period</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Pregnancy in Diabetics - ethnology</subject><subject>Pregnancy Trimester, Third</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>United States</subject><subject>Weight Gain</subject><issn>1540-9996</issn><issn>1931-843X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1LwzAYx_EgipvTo1fJ0UtnXtqkOY7pNmG6i6K3kqZPbEdfZpMy_O9t2RQ8eUoOH3488EXompIpJbG62-7zKSM0mkYhZydoTBWnQRzy99P-H4UkUEqJEbpwbksIY5SQczRiQtFYMTZG7SqdUYN1neElOK990dS6xG9QfOQeL3VR41kLeKGNb1qHfa49fqxt2UFtAD9Dr33vN503TQW450-Nz6Gn-8LnfzbvC52CB3eJzqwuHVwd3wl6XTy8zFfBerN8nM_WgeFM-MByFVkh4phkgqVGiohHPJQ0DUMLVmqQmU3BWJtJk0GqjMiEoUoYyUMhY8Mn6Pawu2ubz64_JKkKZ6AsdQ1N5xIaEyY545T9T6WKYsFCMtDgQE3bONeCTXZtUen2K6EkGYokfZFkKJIMRXp_c5zu0gqyX_2TgH8DBxqHjg</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Barquiel, Beatriz</creator><creator>Herranz, Lucrecia</creator><creator>Hillman, Natalia</creator><creator>Burgos, Ma Ángeles</creator><creator>Grande, Cristina</creator><creator>Tukia, Keleni M</creator><creator>Bartha, José Luis</creator><creator>Pallardo, Luis Felipe</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>201606</creationdate><title>HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes</title><author>Barquiel, Beatriz ; Herranz, Lucrecia ; Hillman, Natalia ; Burgos, Ma Ángeles ; Grande, Cristina ; Tukia, Keleni M ; Bartha, José Luis ; Pallardo, Luis Felipe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-f395f66880d62bc765353471b44fef7ae7dfbecffd7cdeb9c6d6c196c734678c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Birth Weight</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - ethnology</topic><topic>Female</topic><topic>Fetal Macrosomia - ethnology</topic><topic>Fetal Macrosomia - etiology</topic><topic>Gestational Age</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hispanic Americans - statistics & numerical data</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Mothers</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Postprandial Period</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy in Diabetics - blood</topic><topic>Pregnancy in Diabetics - ethnology</topic><topic>Pregnancy Trimester, Third</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>United States</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barquiel, Beatriz</creatorcontrib><creatorcontrib>Herranz, Lucrecia</creatorcontrib><creatorcontrib>Hillman, Natalia</creatorcontrib><creatorcontrib>Burgos, Ma Ángeles</creatorcontrib><creatorcontrib>Grande, Cristina</creatorcontrib><creatorcontrib>Tukia, Keleni M</creatorcontrib><creatorcontrib>Bartha, José Luis</creatorcontrib><creatorcontrib>Pallardo, Luis Felipe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Journal of women's health (Larchmont, N.Y. 2002)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barquiel, Beatriz</au><au>Herranz, Lucrecia</au><au>Hillman, Natalia</au><au>Burgos, Ma Ángeles</au><au>Grande, Cristina</au><au>Tukia, Keleni M</au><au>Bartha, José Luis</au><au>Pallardo, Luis Felipe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes</atitle><jtitle>Journal of women's health (Larchmont, N.Y. 2002)</jtitle><addtitle>J Womens Health (Larchmt)</addtitle><date>2016-06</date><risdate>2016</risdate><volume>25</volume><issue>6</issue><spage>579</spage><epage>585</epage><pages>579-585</pages><issn>1540-9996</issn><eissn>1931-843X</eissn><abstract>Maternal glucose and weight gain are related to neonatal outcome in women with gestational diabetes mellitus (GDM). The aim of this study was to explore the influence of average third-trimester HbA1c and excess gestational weight gain on GDM neonatal complications.
This observational study included 2037 Spanish singleton pregnant women with GDM followed in our Diabetes and Pregnancy Unit. The maternal HbA1c level was measured monthly from GDM diagnosis to delivery. Women were compared by average HbA1c level and weight gain categorized into ≤ or > the current Institute of Medicine (IOM) recommendations for body mass index. The differential effects of these factors on large-for-gestational-age birth weight and a composite of neonatal complications were assessed.
Women with an average third-trimester HbA1c ≥5.0% (n = 1319) gave birth to 7.3% versus 3.8% (p = 0.005) of large-for-gestational-age neonates and 22.0% versus 16.0% (p = 0.006) of neonates with complications. Women with excess gestational weight gain (n = 299) delivered 12.5% versus 5.2% (p < 0.001) of large-for-gestational-age neonates and 24.7% versus 19.0% (p = 0.022) of neonates with complications. In an adjusted multiple logistic regression analysis among mothers exposed to the respective risk factors, ∼47% and 52% of large-for-gestational-age neonates and 32% and 37% of neonatal complications were potentially preventable by attaining an average third-trimester HbA1c level <5.0% and optimizing gestational weight gain.
Average third-trimester HbA1c level ≥5% and gestational weight gain above the IOM recommendation are relevant risk factors for neonatal complications in mothers with gestational diabetes.</abstract><cop>United States</cop><pmid>26918922</pmid><doi>10.1089/jwh.2015.5432</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Birth Weight Blood Glucose - metabolism Body Mass Index Diabetes Mellitus, Type 2 - epidemiology Diabetes, Gestational - blood Diabetes, Gestational - ethnology Female Fetal Macrosomia - ethnology Fetal Macrosomia - etiology Gestational Age Glycated Hemoglobin A - metabolism Hispanic Americans - statistics & numerical data Humans Infant, Newborn Mothers Obesity - complications Obesity - epidemiology Postprandial Period Pregnancy Pregnancy Complications - epidemiology Pregnancy in Diabetics - blood Pregnancy in Diabetics - ethnology Pregnancy Trimester, Third Retrospective Studies Risk Factors Socioeconomic Factors United States Weight Gain |
| title | HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes |
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