Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models
To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of 89Zr-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and...
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| Veröffentlicht in: | Molecular pharmaceutics 2016-07, Vol.13 (7), p.2571-2577 |
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| creator | Park, Ji-Ae Lee, Yong Jin Lee, Ji Woong Yoo, Ran Ji Shin, Un Chol Lee, Kyo Chul Kim, Byung il Kim, Kyeong Min Kim, Jung Young |
| description | To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of 89Zr-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and sodium [18F]fluoride. 89Zr-oxalate exhibited observable higher uptake in a macrophage cell line than in tumor cells. The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using 89Zr-oxalate. Compared to [18F]FDG and sodium [18F]fluoride, 89Zr-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest 89Zr-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, 89Zr-oxalate demonstrated a high level of accumulation in inflammatory lesions. 89Zr-oxalate is a new strategic tool for tumor imaging and inflammatory processes. |
| doi_str_mv | 10.1021/acs.molpharmaceut.6b00411 |
| format | Article |
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The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using 89Zr-oxalate. Compared to [18F]FDG and sodium [18F]fluoride, 89Zr-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest 89Zr-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, 89Zr-oxalate demonstrated a high level of accumulation in inflammatory lesions. 89Zr-oxalate is a new strategic tool for tumor imaging and inflammatory processes.</description><identifier>ISSN: 1543-8384</identifier><identifier>EISSN: 1543-8392</identifier><identifier>DOI: 10.1021/acs.molpharmaceut.6b00411</identifier><identifier>PMID: 27243098</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Arthritis, Rheumatoid - diagnostic imaging ; Cell Line, Tumor ; Fluorodeoxyglucose F18 - analysis ; Fluorodeoxyglucose F18 - chemistry ; Humans ; Inflammation - diagnostic imaging ; Male ; Mice ; Oxalates - analysis ; Oxalates - chemistry ; Positron-Emission Tomography - methods ; RAW 264.7 Cells</subject><ispartof>Molecular pharmaceutics, 2016-07, Vol.13 (7), p.2571-2577</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a363t-241cfe66f0a7cc18924f386d470567163d33a4342e0e9d56128e84405605944d3</citedby><cites>FETCH-LOGICAL-a363t-241cfe66f0a7cc18924f386d470567163d33a4342e0e9d56128e84405605944d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.6b00411$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.molpharmaceut.6b00411$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27243098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Ji-Ae</creatorcontrib><creatorcontrib>Lee, Yong Jin</creatorcontrib><creatorcontrib>Lee, Ji Woong</creatorcontrib><creatorcontrib>Yoo, Ran Ji</creatorcontrib><creatorcontrib>Shin, Un Chol</creatorcontrib><creatorcontrib>Lee, Kyo Chul</creatorcontrib><creatorcontrib>Kim, Byung il</creatorcontrib><creatorcontrib>Kim, Kyeong Min</creatorcontrib><creatorcontrib>Kim, Jung Young</creatorcontrib><title>Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models</title><title>Molecular pharmaceutics</title><addtitle>Mol. Pharmaceutics</addtitle><description>To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of 89Zr-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and sodium [18F]fluoride. 89Zr-oxalate exhibited observable higher uptake in a macrophage cell line than in tumor cells. The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using 89Zr-oxalate. Compared to [18F]FDG and sodium [18F]fluoride, 89Zr-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest 89Zr-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, 89Zr-oxalate demonstrated a high level of accumulation in inflammatory lesions. 89Zr-oxalate is a new strategic tool for tumor imaging and inflammatory processes.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Cell Line, Tumor</subject><subject>Fluorodeoxyglucose F18 - analysis</subject><subject>Fluorodeoxyglucose F18 - chemistry</subject><subject>Humans</subject><subject>Inflammation - diagnostic imaging</subject><subject>Male</subject><subject>Mice</subject><subject>Oxalates - analysis</subject><subject>Oxalates - chemistry</subject><subject>Positron-Emission Tomography - methods</subject><subject>RAW 264.7 Cells</subject><issn>1543-8384</issn><issn>1543-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9Lw0AQxRdRrFa_gqw3D03df9lsjkWqFioVqRdFwjS7oSlJtu4mot_era0Fb55mmHnvDfND6JKSISWMXkPuh7Wt1ktwNeSma4dyQYig9ACd0FjwSPGUHe57JXro1PsVIUzEjB-jHkuY4CRVJ0iPP6DqoC1tg22BX1X64t6i2SdU0BoMHgN-HM_x3IU7DpcNnjRFBXX94xjgeVdbN8DQaPy0NF0Y21LjkWuXrmxLjx-sNpU_Q0cFVN6c72ofPd-O5zf30XR2N7kZTSPgkrcREzQvjJQFgSTPqUqZKLiSWiQklgmVXHMOggtmiEl1LClTRgkRliROhdC8j662uWtn3zvj26wufW6qChpjO59RFQgkSiZJkKZbae6s984U2dqVNbivjJJsAzkLkLM_kLMd5OC92J3pFrXRe-cv1SCIt4JNxsp2rglf_yP4Gw5Fjnk</recordid><startdate>20160705</startdate><enddate>20160705</enddate><creator>Park, Ji-Ae</creator><creator>Lee, Yong Jin</creator><creator>Lee, Ji Woong</creator><creator>Yoo, Ran Ji</creator><creator>Shin, Un Chol</creator><creator>Lee, Kyo Chul</creator><creator>Kim, Byung il</creator><creator>Kim, Kyeong Min</creator><creator>Kim, Jung Young</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160705</creationdate><title>Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models</title><author>Park, Ji-Ae ; Lee, Yong Jin ; Lee, Ji Woong ; Yoo, Ran Ji ; Shin, Un Chol ; Lee, Kyo Chul ; Kim, Byung il ; Kim, Kyeong Min ; Kim, Jung Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a363t-241cfe66f0a7cc18924f386d470567163d33a4342e0e9d56128e84405605944d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Cell Line, Tumor</topic><topic>Fluorodeoxyglucose F18 - analysis</topic><topic>Fluorodeoxyglucose F18 - chemistry</topic><topic>Humans</topic><topic>Inflammation - diagnostic imaging</topic><topic>Male</topic><topic>Mice</topic><topic>Oxalates - analysis</topic><topic>Oxalates - chemistry</topic><topic>Positron-Emission Tomography - methods</topic><topic>RAW 264.7 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ji-Ae</creatorcontrib><creatorcontrib>Lee, Yong Jin</creatorcontrib><creatorcontrib>Lee, Ji Woong</creatorcontrib><creatorcontrib>Yoo, Ran Ji</creatorcontrib><creatorcontrib>Shin, Un Chol</creatorcontrib><creatorcontrib>Lee, Kyo Chul</creatorcontrib><creatorcontrib>Kim, Byung il</creatorcontrib><creatorcontrib>Kim, Kyeong Min</creatorcontrib><creatorcontrib>Kim, Jung Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ji-Ae</au><au>Lee, Yong Jin</au><au>Lee, Ji Woong</au><au>Yoo, Ran Ji</au><au>Shin, Un Chol</au><au>Lee, Kyo Chul</au><au>Kim, Byung il</au><au>Kim, Kyeong Min</au><au>Kim, Jung Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models</atitle><jtitle>Molecular pharmaceutics</jtitle><addtitle>Mol. Pharmaceutics</addtitle><date>2016-07-05</date><risdate>2016</risdate><volume>13</volume><issue>7</issue><spage>2571</spage><epage>2577</epage><pages>2571-2577</pages><issn>1543-8384</issn><eissn>1543-8392</eissn><abstract>To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of 89Zr-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and sodium [18F]fluoride. 89Zr-oxalate exhibited observable higher uptake in a macrophage cell line than in tumor cells. The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using 89Zr-oxalate. Compared to [18F]FDG and sodium [18F]fluoride, 89Zr-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest 89Zr-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, 89Zr-oxalate demonstrated a high level of accumulation in inflammatory lesions. 89Zr-oxalate is a new strategic tool for tumor imaging and inflammatory processes.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27243098</pmid><doi>10.1021/acs.molpharmaceut.6b00411</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Arthritis, Rheumatoid - diagnostic imaging Cell Line, Tumor Fluorodeoxyglucose F18 - analysis Fluorodeoxyglucose F18 - chemistry Humans Inflammation - diagnostic imaging Male Mice Oxalates - analysis Oxalates - chemistry Positron-Emission Tomography - methods RAW 264.7 Cells |
| title | Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models |
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