Dynamic monitoring of GPER-mediated estrogenic effects in breast cancer associated fibroblasts: An alternative role of estrogen in mammary carcinoma development

•Biology aspects of GPER were evaluated by dynamic monitoring of a real time cell analyzer system.•GPER mediate rapid estrogenic actions including cell index increasing, modulation of intracellular calcium and phosphorylation of extracellular signal-regulated kinase1/2.•Estradiol induced slow effect...

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Veröffentlicht in:	Steroids 2016-08, Vol.112, p.1-11
Hauptverfasser:	Luo, Haojun, Liu, Manran, Luo, Shujuan, Yu, Tenghua, Wu, Chengyi, Yang, Guanglun, Tu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzodioxoles - pharmacology Breast cancer Breast Neoplasms - metabolism CAFs Calcium - metabolism Cancer-Associated Fibroblasts - metabolism Cell Adhesion - drug effects Cell Cycle - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Estradiol - pharmacology Estrogenic effects Estrogens - pharmacology Female GPER Humans Immunoblotting Quinolines - pharmacology Receptors, Estrogen - metabolism Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction Tumor microenvironment
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