Priming mobilized peripheral blood mononuclear cells with the “activated platelet supernatant” enhances the efficacy of cell therapy for myocardial infarction of rats

Summary Aim Various methods are used to augment the efficacy of cell therapy in myocardial infarction (MI). In this study, we used the “activated platelet supernatant (APS)” to prime autologous “granulocyte colony‐stimulating factor‐mobilized peripheral blood mononuclear cells (mobPBMCs)” and invest...

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Veröffentlicht in:	Cardiovascular therapeutics 2016-08, Vol.34 (4), p.245-253
Hauptverfasser:	Kang, Jeehoon, Hur, Jin, Kang, Jin‐A, Lee, Hak Seung, Jung, Heewon, Choi, Jae‐Il, Lee, Hwan, Kim, Yong Sook, Ahn, Youngkeun, Kim, Hyo‐Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated platelet supernatant Angiogenic Proteins - metabolism Animals Blood Platelets - metabolism Cell Adhesion Molecules - metabolism Cell priming Cell Proliferation Cell Therapy Cells, Cultured Cytokines - blood Disease Models, Animal Endothelial Cells - metabolism Granulocyte Colony-Stimulating Factor - administration & dosage Granulocyte colony‐stimulating factor‐mobilized peripheral blood mononuclear cells Injections, Subcutaneous Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - transplantation M2 polarization Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - surgery Neovascularization, Physiologic Paracrine Communication Phenotype Platelet Activation Rats, Sprague-Dawley Recovery of Function Subcellular Fractions - metabolism Time Factors Wound Healing
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