Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy
Context: The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status. O...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2016-07, Vol.101 (7), p.2923-2930 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Joon Cho, Geum Heon Park, Jong Lee, Heeyoung Yoo, Seughyun Shin, Soon-Ae Oh, Min-Jeong |
| description | Context:
The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status.
Objective:
This study aimed to identify prepregnancy factors for the development of DM in women with or without GDM in their first pregnancy.
Design and Participants:
This retrospective, observational, cohort study included data for 53 109 women who underwent a National Health Screening Examination through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with follow-up until 2012.
Main Outcomes:
The main outcome of the study was the risk of developing DM after 8 years in women with and without GDM during their first pregnancy.
Results:
The cumulative risks of developing DM after 8 years were 8.4% and 3.3% in women with and without GDM during their first pregnancy, respectively. Old age, a family history of DM, obesity, a high fasting glucose level, and high total cholesterol level were associated with DM development in women without GDM. In women with GDM, a family history of DM, prepregnancy obesity, a high fasting glucose level, and a high total cholesterol level were associated with DM. When stratified by GDM status and the number of prepregnancy risk factors, the number of prepregnancy risk factors was associated with the risk of DM in women with or without GDM. Women with GDM had a higher risk of DM for the same number of prepregnancy risk factors than women without GDM.
Conclusion:
The results show that GDM may be a marker for development of DM in the future because it shares the same risk factors with DM development. Thus, eliminating other risk factors in women with GDM may lead to a reduction in the risk of DM.
GDM is a marker for future DM, as it shares risk factors with DM. Thus, eliminating other risk factors among women with GDM may reduce the risk of future DM. |
| doi_str_mv | 10.1210/jc.2015-3761 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1802469004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1802469004</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4187-fc5b15153284c980c8e96ff6d38a7a63bc05535a089963fdc918ba6e7ae56e243</originalsourceid><addsrcrecordid>eNptkUtr3DAUhUVpaKZpd10HLbuoE70fy5B02kJCs2ihOyFrrjue2NZEkhvy7yszSVYRCHEP3zlcjhD6RMkZZZSc78IZI1Q2XCv6Bq2oFbLR1Oq3aEUIo43V7M8xep_zjhAqhOTv0DHTVFpq2Qq1twn2Cf5OfgqPeO1DiSljn_EVFEhjX_WScexw2ULV_sEQ9yNMZZGuet9WKuMbGIa-zBlfdNWE133KBd8-p35AR50fMnx8ek_Q7_XXX5ffm-uf335cXlw3QVCjmy7IlkoqOTMiWEOCAau6Tm248dor3gYiJZeeGGsV7zbBUtN6BdqDVMAEP0GfD7n7FO9nyMWNfQ51NT9BnLOjhjChLCEL-uWAhhRzTtC5fepHnx4dJW5p1e2CW1p1S6sVP31KntsRNi_wc40VEAfgIQ61gXw3zA-Q3Bb8ULaO1COUNk1NVETXqamX62rjBxtMmxhSPy1fkbPbxTlNtarXt_kPx12TXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1802469004</pqid></control><display><type>article</type><title>Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Joon Cho, Geum ; Heon Park, Jong ; Lee, Heeyoung ; Yoo, Seughyun ; Shin, Soon-Ae ; Oh, Min-Jeong</creator><creatorcontrib>Joon Cho, Geum ; Heon Park, Jong ; Lee, Heeyoung ; Yoo, Seughyun ; Shin, Soon-Ae ; Oh, Min-Jeong</creatorcontrib><description>Context:
The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status.
Objective:
This study aimed to identify prepregnancy factors for the development of DM in women with or without GDM in their first pregnancy.
Design and Participants:
This retrospective, observational, cohort study included data for 53 109 women who underwent a National Health Screening Examination through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with follow-up until 2012.
Main Outcomes:
The main outcome of the study was the risk of developing DM after 8 years in women with and without GDM during their first pregnancy.
Results:
The cumulative risks of developing DM after 8 years were 8.4% and 3.3% in women with and without GDM during their first pregnancy, respectively. Old age, a family history of DM, obesity, a high fasting glucose level, and high total cholesterol level were associated with DM development in women without GDM. In women with GDM, a family history of DM, prepregnancy obesity, a high fasting glucose level, and a high total cholesterol level were associated with DM. When stratified by GDM status and the number of prepregnancy risk factors, the number of prepregnancy risk factors was associated with the risk of DM in women with or without GDM. Women with GDM had a higher risk of DM for the same number of prepregnancy risk factors than women without GDM.
Conclusion:
The results show that GDM may be a marker for development of DM in the future because it shares the same risk factors with DM development. Thus, eliminating other risk factors in women with GDM may lead to a reduction in the risk of DM.
GDM is a marker for future DM, as it shares risk factors with DM. Thus, eliminating other risk factors among women with GDM may reduce the risk of future DM.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2015-3761</identifier><identifier>PMID: 27159192</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adult ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes, Gestational - epidemiology ; Female ; Humans ; Incidence ; Parity ; Pregnancy ; Republic of Korea - epidemiology ; Retrospective Studies ; Risk Factors ; Time Factors ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2016-07, Vol.101 (7), p.2923-2930</ispartof><rights>Copyright © 2016 by the Endocrine Society</rights><rights>Copyright © 2016 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4187-fc5b15153284c980c8e96ff6d38a7a63bc05535a089963fdc918ba6e7ae56e243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27159192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joon Cho, Geum</creatorcontrib><creatorcontrib>Heon Park, Jong</creatorcontrib><creatorcontrib>Lee, Heeyoung</creatorcontrib><creatorcontrib>Yoo, Seughyun</creatorcontrib><creatorcontrib>Shin, Soon-Ae</creatorcontrib><creatorcontrib>Oh, Min-Jeong</creatorcontrib><title>Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status.
Objective:
This study aimed to identify prepregnancy factors for the development of DM in women with or without GDM in their first pregnancy.
Design and Participants:
This retrospective, observational, cohort study included data for 53 109 women who underwent a National Health Screening Examination through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with follow-up until 2012.
Main Outcomes:
The main outcome of the study was the risk of developing DM after 8 years in women with and without GDM during their first pregnancy.
Results:
The cumulative risks of developing DM after 8 years were 8.4% and 3.3% in women with and without GDM during their first pregnancy, respectively. Old age, a family history of DM, obesity, a high fasting glucose level, and high total cholesterol level were associated with DM development in women without GDM. In women with GDM, a family history of DM, prepregnancy obesity, a high fasting glucose level, and a high total cholesterol level were associated with DM. When stratified by GDM status and the number of prepregnancy risk factors, the number of prepregnancy risk factors was associated with the risk of DM in women with or without GDM. Women with GDM had a higher risk of DM for the same number of prepregnancy risk factors than women without GDM.
Conclusion:
The results show that GDM may be a marker for development of DM in the future because it shares the same risk factors with DM development. Thus, eliminating other risk factors in women with GDM may lead to a reduction in the risk of DM.
GDM is a marker for future DM, as it shares risk factors with DM. Thus, eliminating other risk factors among women with GDM may reduce the risk of future DM.</description><subject>Adult</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtr3DAUhUVpaKZpd10HLbuoE70fy5B02kJCs2ihOyFrrjue2NZEkhvy7yszSVYRCHEP3zlcjhD6RMkZZZSc78IZI1Q2XCv6Bq2oFbLR1Oq3aEUIo43V7M8xep_zjhAqhOTv0DHTVFpq2Qq1twn2Cf5OfgqPeO1DiSljn_EVFEhjX_WScexw2ULV_sEQ9yNMZZGuet9WKuMbGIa-zBlfdNWE133KBd8-p35AR50fMnx8ek_Q7_XXX5ffm-uf335cXlw3QVCjmy7IlkoqOTMiWEOCAau6Tm248dor3gYiJZeeGGsV7zbBUtN6BdqDVMAEP0GfD7n7FO9nyMWNfQ51NT9BnLOjhjChLCEL-uWAhhRzTtC5fepHnx4dJW5p1e2CW1p1S6sVP31KntsRNi_wc40VEAfgIQ61gXw3zA-Q3Bb8ULaO1COUNk1NVETXqamX62rjBxtMmxhSPy1fkbPbxTlNtarXt_kPx12TXw</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Joon Cho, Geum</creator><creator>Heon Park, Jong</creator><creator>Lee, Heeyoung</creator><creator>Yoo, Seughyun</creator><creator>Shin, Soon-Ae</creator><creator>Oh, Min-Jeong</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy</title><author>Joon Cho, Geum ; Heon Park, Jong ; Lee, Heeyoung ; Yoo, Seughyun ; Shin, Soon-Ae ; Oh, Min-Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4187-fc5b15153284c980c8e96ff6d38a7a63bc05535a089963fdc918ba6e7ae56e243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes, Gestational - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joon Cho, Geum</creatorcontrib><creatorcontrib>Heon Park, Jong</creatorcontrib><creatorcontrib>Lee, Heeyoung</creatorcontrib><creatorcontrib>Yoo, Seughyun</creatorcontrib><creatorcontrib>Shin, Soon-Ae</creatorcontrib><creatorcontrib>Oh, Min-Jeong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joon Cho, Geum</au><au>Heon Park, Jong</au><au>Lee, Heeyoung</au><au>Yoo, Seughyun</au><au>Shin, Soon-Ae</au><au>Oh, Min-Jeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2016-07</date><risdate>2016</risdate><volume>101</volume><issue>7</issue><spage>2923</spage><epage>2930</epage><pages>2923-2930</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status.
Objective:
This study aimed to identify prepregnancy factors for the development of DM in women with or without GDM in their first pregnancy.
Design and Participants:
This retrospective, observational, cohort study included data for 53 109 women who underwent a National Health Screening Examination through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with follow-up until 2012.
Main Outcomes:
The main outcome of the study was the risk of developing DM after 8 years in women with and without GDM during their first pregnancy.
Results:
The cumulative risks of developing DM after 8 years were 8.4% and 3.3% in women with and without GDM during their first pregnancy, respectively. Old age, a family history of DM, obesity, a high fasting glucose level, and high total cholesterol level were associated with DM development in women without GDM. In women with GDM, a family history of DM, prepregnancy obesity, a high fasting glucose level, and a high total cholesterol level were associated with DM. When stratified by GDM status and the number of prepregnancy risk factors, the number of prepregnancy risk factors was associated with the risk of DM in women with or without GDM. Women with GDM had a higher risk of DM for the same number of prepregnancy risk factors than women without GDM.
Conclusion:
The results show that GDM may be a marker for development of DM in the future because it shares the same risk factors with DM development. Thus, eliminating other risk factors in women with GDM may lead to a reduction in the risk of DM.
GDM is a marker for future DM, as it shares risk factors with DM. Thus, eliminating other risk factors among women with GDM may reduce the risk of future DM.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>27159192</pmid><doi>10.1210/jc.2015-3761</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2016-07, Vol.101 (7), p.2923-2930 |
| issn | 0021-972X 1945-7197 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes, Gestational - epidemiology Female Humans Incidence Parity Pregnancy Republic of Korea - epidemiology Retrospective Studies Risk Factors Time Factors Young Adult |
| title | Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy |
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