Human DNA Glycosylases Involved in the Repair of Oxidatively Damaged DNA

Reactive oxygen species from endogenous and environmental sources induce oxidative damage to DNA, and hence pose an enormous threat to the genetic integrity of cells. Such oxidative DNA damage is restored by the base excision repair (BER) pathway that is conserved from bacteria to humans and is init...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(4), pp.480-485
Hauptverfasser:	Ide, Hiroshi, Kotera, Mitsuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	action mechanism Animals anticancer drug development Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use covalent trapping DNA Damage DNA glycosylase DNA Glycosylases - metabolism DNA Repair Humans Neoplasms - drug therapy Neoplasms - genetics Oxidation-Reduction oxidative DNA damage Reactive Oxygen Species - metabolism Reactive Oxygen Species - toxicity
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