Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy
Follow-up information on subsequent pregnancies after mifepristone (RU486)-induced abortion is scarce. The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998–2001 at antenatal clinics in Beijin...
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| Veröffentlicht in: | American journal of epidemiology 2004-07, Vol.160 (2), p.110-117 |
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| creator | Chen, Aimin Yuan, Wei Meirik, Olav Wang, Xianmi Wu, Shi-Zhong Zhou, Lifeng Luo, Lin Gao, Ersheng Cheng, Yimin |
| description | Follow-up information on subsequent pregnancies after mifepristone (RU486)-induced abortion is scarce. The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998–2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China, the authors enrolled 4,925 women with no history of induced abortion, 4,931 women with one previous mifepristone-induced abortion, and 4,800 women with one previous surgical abortion and followed them through pregnancy and childbirth. The adjusted odds ratio for preterm delivery in women with one mifepristone abortion compared with women with no abortion was 0.77 (95% confidence interval: 0.61, 0.98). Although the mean birth weight of infants born to women with mifepristone abortion was 33 g (95% confidence interval: 17, 49) higher than that of infants born to women with no abortion, the frequencies of low birth weight and mean lengths of pregnancy were similar. There were no significant differences in risk of preterm delivery, frequency of low birth weight, or mean infant birth weight in the comparisons of women with previous mifepristone abortion and women with surgical abortion. This study suggests that one early abortion induced by mifepristone in nulliparous women has no adverse effects on the outcome of a subsequent pregnancy. |
| doi_str_mv | 10.1093/aje/kwh182 |
| format | Article |
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The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998–2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China, the authors enrolled 4,925 women with no history of induced abortion, 4,931 women with one previous mifepristone-induced abortion, and 4,800 women with one previous surgical abortion and followed them through pregnancy and childbirth. The adjusted odds ratio for preterm delivery in women with one mifepristone abortion compared with women with no abortion was 0.77 (95% confidence interval: 0.61, 0.98). Although the mean birth weight of infants born to women with mifepristone abortion was 33 g (95% confidence interval: 17, 49) higher than that of infants born to women with no abortion, the frequencies of low birth weight and mean lengths of pregnancy were similar. There were no significant differences in risk of preterm delivery, frequency of low birth weight, or mean infant birth weight in the comparisons of women with previous mifepristone abortion and women with surgical abortion. This study suggests that one early abortion induced by mifepristone in nulliparous women has no adverse effects on the outcome of a subsequent pregnancy.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwh182</identifier><identifier>PMID: 15234931</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Abortifacient Agents, Steroidal - adverse effects ; Abortion ; Abortion, Spontaneous - epidemiology ; Analysis. Health state ; Babies ; Biological and medical sciences ; Birth control ; Birth weight ; Births ; Case-Control Studies ; China - epidemiology ; confidence interval ; Diseases of mother, fetus and pregnancy ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; induced ; Induced abortion. Therapeutic abortion ; infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; labor ; low birth weight ; Maternal Exposure - adverse effects ; Medical sciences ; mifepristone ; Mifepristone - adverse effects ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; premature ; Prescription drugs ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; standard deviation ; Studies ; Women</subject><ispartof>American journal of epidemiology, 2004-07, Vol.160 (2), p.110-117</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jul 15, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-def7b423d91e88fa8e4579da16659f352d48bd3893d1de3f6529993ab70983433</citedby><cites>FETCH-LOGICAL-c445t-def7b423d91e88fa8e4579da16659f352d48bd3893d1de3f6529993ab70983433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15988069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15234931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Aimin</creatorcontrib><creatorcontrib>Yuan, Wei</creatorcontrib><creatorcontrib>Meirik, Olav</creatorcontrib><creatorcontrib>Wang, Xianmi</creatorcontrib><creatorcontrib>Wu, Shi-Zhong</creatorcontrib><creatorcontrib>Zhou, Lifeng</creatorcontrib><creatorcontrib>Luo, Lin</creatorcontrib><creatorcontrib>Gao, Ersheng</creatorcontrib><creatorcontrib>Cheng, Yimin</creatorcontrib><title>Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Follow-up information on subsequent pregnancies after mifepristone (RU486)-induced abortion is scarce. The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998–2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China, the authors enrolled 4,925 women with no history of induced abortion, 4,931 women with one previous mifepristone-induced abortion, and 4,800 women with one previous surgical abortion and followed them through pregnancy and childbirth. The adjusted odds ratio for preterm delivery in women with one mifepristone abortion compared with women with no abortion was 0.77 (95% confidence interval: 0.61, 0.98). Although the mean birth weight of infants born to women with mifepristone abortion was 33 g (95% confidence interval: 17, 49) higher than that of infants born to women with no abortion, the frequencies of low birth weight and mean lengths of pregnancy were similar. There were no significant differences in risk of preterm delivery, frequency of low birth weight, or mean infant birth weight in the comparisons of women with previous mifepristone abortion and women with surgical abortion. This study suggests that one early abortion induced by mifepristone in nulliparous women has no adverse effects on the outcome of a subsequent pregnancy.</description><subject>Abortifacient Agents, Steroidal - adverse effects</subject><subject>Abortion</subject><subject>Abortion, Spontaneous - epidemiology</subject><subject>Analysis. Health state</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Birth weight</subject><subject>Births</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>confidence interval</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>induced</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>infant</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>labor</subject><subject>low birth weight</subject><subject>Maternal Exposure - adverse effects</subject><subject>Medical sciences</subject><subject>mifepristone</subject><subject>Mifepristone - adverse effects</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>premature</subject><subject>Prescription drugs</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>standard deviation</subject><subject>Studies</subject><subject>Women</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0FtLHDEUwPFQWuqqfekHkKGgD4WpuU_yuIiXFm-gUulLyExO2llnE01mqPvtTdmllj6dh_PjcPgj9JHgLwRrdmgXcPjw-xdR9A2aEd7IWlIh36IZxpjWmkq6hbZzXmBMiBb4PdoigjKuGZmhy4vew2Pq8xgD1H1wUweuOrZpWFXzNqaxj6GywVVX09jFJVTRVzdTm-FpgjBW320Yi79O8DPY0K120TtvhwwfNnMH3Z0c3x6d1edXp1-P5ud1x7kYawe-aTllThNQylsFXDTaWSKl0J4J6rhqHVOaOeKAeSmo1prZtsFaMc7YDjpY331MsXySR7PscwfDYAPEKRuiMKWYqwI__QcXcUqh_GYoEwoXSAr6vEZdijkn8KYUWdq0MgSbP4lNSWzWiQve21yc2iW4V7ppWsD-Btjc2cGnEqbP_zitFJa6uHrtSnx4_ru36cHIhjXCnN3_MJf3Jw3VF98MZi8hQ5LU</recordid><startdate>20040715</startdate><enddate>20040715</enddate><creator>Chen, Aimin</creator><creator>Yuan, Wei</creator><creator>Meirik, Olav</creator><creator>Wang, Xianmi</creator><creator>Wu, Shi-Zhong</creator><creator>Zhou, Lifeng</creator><creator>Luo, Lin</creator><creator>Gao, Ersheng</creator><creator>Cheng, Yimin</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope></search><sort><creationdate>20040715</creationdate><title>Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy</title><author>Chen, Aimin ; Yuan, Wei ; Meirik, Olav ; Wang, Xianmi ; Wu, Shi-Zhong ; Zhou, Lifeng ; Luo, Lin ; Gao, Ersheng ; Cheng, Yimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-def7b423d91e88fa8e4579da16659f352d48bd3893d1de3f6529993ab70983433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abortifacient Agents, Steroidal - adverse effects</topic><topic>Abortion</topic><topic>Abortion, Spontaneous - epidemiology</topic><topic>Analysis. Health state</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Birth weight</topic><topic>Births</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>confidence interval</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>induced</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>infant</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>labor</topic><topic>low birth weight</topic><topic>Maternal Exposure - adverse effects</topic><topic>Medical sciences</topic><topic>mifepristone</topic><topic>Mifepristone - adverse effects</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>premature</topic><topic>Prescription drugs</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>standard deviation</topic><topic>Studies</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Aimin</creatorcontrib><creatorcontrib>Yuan, Wei</creatorcontrib><creatorcontrib>Meirik, Olav</creatorcontrib><creatorcontrib>Wang, Xianmi</creatorcontrib><creatorcontrib>Wu, Shi-Zhong</creatorcontrib><creatorcontrib>Zhou, Lifeng</creatorcontrib><creatorcontrib>Luo, Lin</creatorcontrib><creatorcontrib>Gao, Ersheng</creatorcontrib><creatorcontrib>Cheng, Yimin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Aimin</au><au>Yuan, Wei</au><au>Meirik, Olav</au><au>Wang, Xianmi</au><au>Wu, Shi-Zhong</au><au>Zhou, Lifeng</au><au>Luo, Lin</au><au>Gao, Ersheng</au><au>Cheng, Yimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2004-07-15</date><risdate>2004</risdate><volume>160</volume><issue>2</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Follow-up information on subsequent pregnancies after mifepristone (RU486)-induced abortion is scarce. The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998–2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China, the authors enrolled 4,925 women with no history of induced abortion, 4,931 women with one previous mifepristone-induced abortion, and 4,800 women with one previous surgical abortion and followed them through pregnancy and childbirth. The adjusted odds ratio for preterm delivery in women with one mifepristone abortion compared with women with no abortion was 0.77 (95% confidence interval: 0.61, 0.98). Although the mean birth weight of infants born to women with mifepristone abortion was 33 g (95% confidence interval: 17, 49) higher than that of infants born to women with no abortion, the frequencies of low birth weight and mean lengths of pregnancy were similar. There were no significant differences in risk of preterm delivery, frequency of low birth weight, or mean infant birth weight in the comparisons of women with previous mifepristone abortion and women with surgical abortion. This study suggests that one early abortion induced by mifepristone in nulliparous women has no adverse effects on the outcome of a subsequent pregnancy.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>15234931</pmid><doi>10.1093/aje/kwh182</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Abortifacient Agents, Steroidal - adverse effects Abortion Abortion, Spontaneous - epidemiology Analysis. Health state Babies Biological and medical sciences Birth control Birth weight Births Case-Control Studies China - epidemiology confidence interval Diseases of mother, fetus and pregnancy Epidemiology Female Follow-Up Studies General aspects Gynecology. Andrology. Obstetrics Humans induced Induced abortion. Therapeutic abortion infant Infant, Low Birth Weight Infant, Newborn Infant, Premature labor low birth weight Maternal Exposure - adverse effects Medical sciences mifepristone Mifepristone - adverse effects Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta premature Prescription drugs Public health. Hygiene Public health. Hygiene-occupational medicine standard deviation Studies Women |
| title | Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy |
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