Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

Epstein–Barr virus associated lymphoproliferative disorder (EBV‐LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS)...

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Veröffentlicht in:Pediatrics international 2016-05, Vol.58 (5), p.388-390
Hauptverfasser: Nakashima, Kentaro, Kodama, Yuichi, Nishikawa, Takuro, Nishimura, Miho, Ito, Nobuhiro, Fukano, Reiji, Nomura, Yuko, Ueba, Tetsuya, Inoue, Tooru, Oshima, Koichi, Okamura, Jun, Inagaki, Jiro
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycin
Central nervous system
Chemotherapy
Cyclophosphamide
Epstein-Barr virus
Epstein‐Barr virus‐associated lymphoproliferative disorder
high‐dose methotrexate
Immunodeficiency
Immunotherapy
Liver
Lymphatic diseases
Lymphocytes
Methotrexate
Monoclonal antibodies
Nervous system
Pediatrics
Rhabdomyosarcoma
Rituximab
Solid tumors
Vincristine
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Zusammenfassung:Epstein–Barr virus associated lymphoproliferative disorder (EBV‐LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV‐LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high‐dose methotrexate (HD‐MTX) for CNS EBV‐LPD and then treated with rituximab in addition to HD‐MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD‐MTX might be effective therapy for CNS EBV‐LPD.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.12812