Delta-Short Consensus Repeat 4-Decay Accelerating Factor (DAF: CD55) Inhibits Complement-Mediated Cytolysis but Not NK Cell-Mediated Cytolysis

NK cells play a critical role in the rejection of xenografts. In this study, we report on an investigation of the effect of complement regulatory protein, a decay accelerating factor (DAF: CD55), in particular, on NK cell-mediated cytolysis. Amelioration of human NK cell-mediated pig endothelial cel...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-09, Vol.173 (6), p.3945-3952
Hauptverfasser:	Miyagawa, Shuji, Kubo, Tomoko, Matsunami, Katsuyoshi, Kusama, Tamiko, Beppu, Keiko, Nozaki, Hiroshi, Moritan, Toshiyuki, Ahn, Curie, Kim, Jae Young, Fukuta, Daisuke, Shirakura, Ryota
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Blotting, Western CD55 Antigens - biosynthesis CD55 Antigens - blood CD55 Antigens - genetics CD55 Antigens - physiology Cell Line Chromium Radioisotopes - metabolism Complement Activation - genetics Complement Inactivator Proteins - biosynthesis Complement Inactivator Proteins - genetics Complement Inactivator Proteins - physiology Consensus Sequence - genetics Cytotoxicity Tests, Immunologic - methods Cytotoxicity, Immunologic - genetics Down-Regulation - genetics Down-Regulation - immunology Fibroblasts - immunology Fibroblasts - metabolism Flow Cytometry Humans Interferon-gamma - metabolism K562 Cells Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Mutagenesis, Site-Directed Repetitive Sequences, Amino Acid - genetics Sequence Deletion Swine Transfection
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