Isolation of Adda from microcystin-LR by microbial degradation
The intact Adda was isolated from microcystin-LR by a microbial degradation using an isolated Sphingomonas strain, B-9. The reaction of microcystin-LR with cell extract of this strain proceeded smoothly to give the final degradation product by way of two intermediates, linearized microcystin-LR and...
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| Veröffentlicht in: | Toxicon (Oxford) 2004-07, Vol.44 (1), p.107-109 |
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| container_title | Toxicon (Oxford) |
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| creator | Harada, Ken-ichi Imanishi, Susumu Kato, Hajime Mizuno, Masayoshi Ito, Emiko Tsuji, Kiyomi |
| description | The intact Adda was isolated from microcystin-LR by a microbial degradation using an isolated
Sphingomonas strain, B-9. The reaction of microcystin-LR with cell extract of this strain proceeded smoothly to give the final degradation product by way of two intermediates, linearized microcystin-LR and a tetrapeptide. The purified Adda that was structurally characterized using various spectral data did not show the toxicity to mice or inhibition to protein phosphatase activity in contrast to the native toxin. |
| doi_str_mv | 10.1016/j.toxicon.2004.04.003 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Toxicon (Oxford), 2004-07, Vol.44 (1), p.107-109 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adda Amino Acids - chemistry Amino Acids - isolation & purification Bacterial Toxins - metabolism Bacteriology Biodegradation, Environmental Biological and medical sciences Cyanobacteria - chemistry Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Marine Toxins - metabolism Microbial degradation Microbiology Microcystin Microcystins Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Sphingomonas Sphingomonas - metabolism Toxicity |
| title | Isolation of Adda from microcystin-LR by microbial degradation |
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