Effect of tacrine on EEG slowing in the rat:: Enhancement by concurrent monoamine therapy

A dominant electrophysiological characteristic of Alzheimer’s disease (AD) is the loss of desynchronized EEG activity and shift toward low-frequency EEG synchronization. In rats, similar EEG changes resulted from administering the anti-cholinergic scopolamine (1 mg/kg) and the monoamine depletor res...

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Veröffentlicht in:	Neurobiology of aging 2000-01, Vol.21 (1), p.135-143
Hauptverfasser:	Dringenberg, Hans C, Diavolitsis, Peter, Noseworthy, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Adrenergic Uptake Inhibitors - pharmacology Alzheimer’s disease Animals Biogenic Monoamines - metabolism Biogenic Monoamines - pharmacology Biological and medical sciences Cholinesterase Inhibitors - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Drug Synergism EEG restoration EEG slowing Electroencephalography - drug effects Fluoxetine Fluoxetine - pharmacology Imipramine Imipramine - pharmacology Male Medical sciences Monoamine Oxidase Inhibitors - pharmacology Monoamines Muscarinic Antagonists - pharmacology Neurology Pargyline Pargyline - pharmacology Rats Rats, Long-Evans Reserpine - pharmacology Scopolamine - pharmacology Serotonin Uptake Inhibitors - pharmacology Tacrine Tacrine - pharmacology
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