Novel RIPK3 inhibitors discovered through a structure-based approach exert post-ischemic neuroprotection

Necroptosis or programmed necrosis is evident in various neurological disorders such as ischemic stroke. Receptor interacting serine/threonine protein kinase 3 (RIPK3) is one of the crucial targets of necroptosis and inhibition of this protein exerts neuroprotection. However, knowledge regarding the...

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Veröffentlicht in:Molecular diversity 2016-08, Vol.20 (3), p.719-728
Hauptverfasser: Fayaz, S. M., Suvanish Kumar, V. S., Davis, Charles K., Rajanikant, G. K.
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Sprache:eng
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