Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: final results of the AGMT CLL-8a Mabtenance randomised trial

Summary Background In many patients with chronic lymphocytic leukaemia requiring treatment, induction therapy with rituximab plus chemotherapy improves outcomes compared with chemotherapy alone. In this study we aimed to investigate the potential of rituximab maintenance therapy to prolong disease c...

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Veröffentlicht in:	The Lancet. Haematology 2016-07, Vol.3 (7), p.e317-e329
Hauptverfasser:	Greil, Richard, Prof, Obrtlíková, Petra, MD, Smolej, Lukáš, MD, Kozák, Tomáš, Prof, Steurer, Michael, Prof, Andel, Johannes, MD, Burgstaller, Sonja, MD, Mikušková, Eva, MD, Gercheva, Liana, Prof, Nösslinger, Thomas, MD, Papajík, Tomáš, Prof, Ladická, Miriam, MD, Girschikofsky, Michael, MD, Hrubiško, Mikuláš, Prof, Jäger, Ulrich, Prof, Fridrik, Michael, MD, Pecherstorfer, Martin, Prof, Králiková, Eva, MD, Burcoveanu, Cristina, MD, Spasov, Emil, MD, Petzer, Andreas, Prof, Mihaylov, Georgi, MD, Raynov, Julian, MD, Oexle, Horst, MD, Zabernigg, August, MD, Flochová, Emília, MD, Palášthy, Stanislav, MD, Stehlíková, Olga, Doubek, Michael, Prof, Altenhofer, Petra, MD, Pleyer, Lisa, MD, Melchardt, Thomas, MD, Klingler, Anton, PhD, Mayer, Jiří, Prof, Egle, Alexander, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bendamustine Hydrochloride - administration & dosage Cyclophosphamide - administration & dosage Female Hematology, Oncology and Palliative Medicine Humans Immunotherapy Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology Male Middle Aged Neoplasm Staging Remission Induction Rituximab - administration & dosage Survival Rate Vidarabine - administration & dosage Vidarabine - analogs & derivatives
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