Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma
We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more...
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| Veröffentlicht in: | Internal Medicine 2016/07/01, Vol.55(13), pp.1807-1810 |
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| container_title | Internal Medicine |
| container_volume | 55 |
| creator | Kawakami, Toru Hirabayashi, Yukio Kawakami, Fumihiro Isobe, Rei Kaneko, Naoto Mimura, Yuto Ito, Toshiro Furuta, Kiyoshi Shimazaki, Mami Nakazawa, Hideyuki Kitano, Kiyoshi |
| description | We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies. |
| doi_str_mv | 10.2169/internalmedicine.55.6327 |
| format | Article |
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Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.55.6327</identifier><identifier>PMID: 27374689</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged, 80 and over ; Antiviral Agents - therapeutic use ; Cyclopentanes - therapeutic use ; drug resistance ; Drug Resistance, Viral ; Guanidines - therapeutic use ; Humans ; influenza ; Influenza A Virus, H3N2 Subtype ; Influenza, Human - virology ; Lymphoma - drug therapy ; Male ; malignant lymphoma ; Mutation ; Neuraminidase - antagonists & inhibitors ; Neuraminidase - genetics ; Oseltamivir - therapeutic use ; persistent infection</subject><ispartof>Internal Medicine, 2016/07/01, Vol.55(13), pp.1807-1810</ispartof><rights>2016 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c529t-7d8e02c5128e57e8d5e9c270cfb4d14c960231bcce858b9447034975c7c612413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27374689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, Toru</creatorcontrib><creatorcontrib>Hirabayashi, Yukio</creatorcontrib><creatorcontrib>Kawakami, Fumihiro</creatorcontrib><creatorcontrib>Isobe, Rei</creatorcontrib><creatorcontrib>Kaneko, Naoto</creatorcontrib><creatorcontrib>Mimura, Yuto</creatorcontrib><creatorcontrib>Ito, Toshiro</creatorcontrib><creatorcontrib>Furuta, Kiyoshi</creatorcontrib><creatorcontrib>Shimazaki, Mami</creatorcontrib><creatorcontrib>Nakazawa, Hideyuki</creatorcontrib><creatorcontrib>Kitano, Kiyoshi</creatorcontrib><title>Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.</description><subject>Aged, 80 and over</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Cyclopentanes - therapeutic use</subject><subject>drug resistance</subject><subject>Drug Resistance, Viral</subject><subject>Guanidines - therapeutic use</subject><subject>Humans</subject><subject>influenza</subject><subject>Influenza A Virus, H3N2 Subtype</subject><subject>Influenza, Human - virology</subject><subject>Lymphoma - drug therapy</subject><subject>Male</subject><subject>malignant lymphoma</subject><subject>Mutation</subject><subject>Neuraminidase - antagonists & inhibitors</subject><subject>Neuraminidase - genetics</subject><subject>Oseltamivir - therapeutic use</subject><subject>persistent infection</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLtOwzAUhi0EgnJ5BeSRJcWXOLZHVK5SEQzAarnOSWuUOMVOhvL0JGrpgFiOh__7z5E_hDAlU0YLfe1DBzHYuoHSOx9gKsS04EweoAnluc4k4-IQTYimKmPDOEGnKX0SwpXU7BidMMllXig9Qe4VYvKpg9Dhp1CB63wbcFvh29gvswhjZrdZ3UP4tvgGf_jYJ1z20Yclnq2gabsVRLve4KqN-NnWfhnGznzTrFdtY8_RUWXrBBe79wy939-9zR6z-cvD0-xmnjnBdJfJUgFhTlCmQEhQpQDtmCSuWuQlzZ0uCON04RwooRY6zyUZ_iqFk66gLKf8DF1t965j-9VD6kzjk4O6tgHaPhmqCFUFo4oPqNqiLrYpRajMOvrGxo2hxIyKzV_FRggzKh6ql7sr_WII98VfpwPwsgU-B3VL2AM2dt7V8O9myse5O7En3cpGA4H_AJBEmy8</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kawakami, Toru</creator><creator>Hirabayashi, Yukio</creator><creator>Kawakami, Fumihiro</creator><creator>Isobe, Rei</creator><creator>Kaneko, Naoto</creator><creator>Mimura, Yuto</creator><creator>Ito, Toshiro</creator><creator>Furuta, Kiyoshi</creator><creator>Shimazaki, Mami</creator><creator>Nakazawa, Hideyuki</creator><creator>Kitano, Kiyoshi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma</title><author>Kawakami, Toru ; Hirabayashi, Yukio ; Kawakami, Fumihiro ; Isobe, Rei ; Kaneko, Naoto ; Mimura, Yuto ; Ito, Toshiro ; Furuta, Kiyoshi ; Shimazaki, Mami ; Nakazawa, Hideyuki ; Kitano, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-7d8e02c5128e57e8d5e9c270cfb4d14c960231bcce858b9447034975c7c612413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged, 80 and over</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Cyclopentanes - therapeutic use</topic><topic>drug resistance</topic><topic>Drug Resistance, Viral</topic><topic>Guanidines - therapeutic use</topic><topic>Humans</topic><topic>influenza</topic><topic>Influenza A Virus, H3N2 Subtype</topic><topic>Influenza, Human - virology</topic><topic>Lymphoma - drug therapy</topic><topic>Male</topic><topic>malignant lymphoma</topic><topic>Mutation</topic><topic>Neuraminidase - antagonists & inhibitors</topic><topic>Neuraminidase - genetics</topic><topic>Oseltamivir - therapeutic use</topic><topic>persistent infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Toru</creatorcontrib><creatorcontrib>Hirabayashi, Yukio</creatorcontrib><creatorcontrib>Kawakami, Fumihiro</creatorcontrib><creatorcontrib>Isobe, Rei</creatorcontrib><creatorcontrib>Kaneko, Naoto</creatorcontrib><creatorcontrib>Mimura, Yuto</creatorcontrib><creatorcontrib>Ito, Toshiro</creatorcontrib><creatorcontrib>Furuta, Kiyoshi</creatorcontrib><creatorcontrib>Shimazaki, Mami</creatorcontrib><creatorcontrib>Nakazawa, Hideyuki</creatorcontrib><creatorcontrib>Kitano, Kiyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Toru</au><au>Hirabayashi, Yukio</au><au>Kawakami, Fumihiro</au><au>Isobe, Rei</au><au>Kaneko, Naoto</au><au>Mimura, Yuto</au><au>Ito, Toshiro</au><au>Furuta, Kiyoshi</au><au>Shimazaki, Mami</au><au>Nakazawa, Hideyuki</au><au>Kitano, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>55</volume><issue>13</issue><spage>1807</spage><epage>1810</epage><pages>1807-1810</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. 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| language | eng |
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| subjects | Aged, 80 and over Antiviral Agents - therapeutic use Cyclopentanes - therapeutic use drug resistance Drug Resistance, Viral Guanidines - therapeutic use Humans influenza Influenza A Virus, H3N2 Subtype Influenza, Human - virology Lymphoma - drug therapy Male malignant lymphoma Mutation Neuraminidase - antagonists & inhibitors Neuraminidase - genetics Oseltamivir - therapeutic use persistent infection |
| title | Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma |
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