MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis

Background/Aims: Osteoporosis is a progressive bone disease characterized by a decrease in bone mass and density, which results in an increased risk of fractures. Mesenchymal stem cells (MSCs) are progenitor cells that can differentiate into osteoblasts, osteocytes and adipocytes in bone and fat for...

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Veröffentlicht in:	Cellular physiology and biochemistry 2016-01, Vol.39 (1), p.253-265
Hauptverfasser:	You, Li, Pan, Ling, Chen, Lin, Gu, Wensha, Chen, Jinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Adipogenesis - genetics Adult Aged Animals Cell Differentiation - genetics Cells, Cultured Disease Models, Animal Female Gene Expression Profiling - methods Humans MEF2 Transcription Factors - genetics Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mice, Inbred BALB C MicroRNAs - blood MicroRNAs - genetics Middle Aged miRNA Original Paper Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - genetics Osteogenic differentiation Osteoporosis Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - pathology Ovariectomy Reverse Transcriptase Polymerase Chain Reaction RNA Interference
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