Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children
This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children. Two populations chronically exposed to either high (41 children) or low (39 children) levels of As and Pb were analyzed using the Wechs...
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| Veröffentlicht in: | Environmental research 2001-02, Vol.85 (2), p.69-76 |
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| creator | Calderón, J. Navarro, M.E. Jimenez-Capdeville, M.E. Santos-Diaz, M.A. Golden, A. Rodriguez-Leyva, I. Borja-Aburto, V. Dı́az-Barriga, F. |
| description | This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children. Two populations chronically exposed to either high (41 children) or low (39 children) levels of As and Pb were analyzed using the Wechsler Intelligence Scale for Children, Revised Version, for México (WISC-RM). Geometric means of urinary arsenic (AsU) and lead in blood (PbB) were 62.9±0.03 (μgAs/g creatinine) and 8.9±0.03 (μg/dl) for the exposed group and 40.2±0.03 (μgAs/g creatinine) and 9.7±0.02 (μg/dl) for the reference group. The height for age index (HAI) was used as an indicator of chronic malnutrition and sociodemographic information was obtained with a questionnaire. Lead and arsenic were measured by atomic absorption spectrophotometry. Data on full, verbal, and performance intelligence quotients (IQ) scores, long-term memory, linguistic abstraction, attention span, and visuospatial organization were obtained through the WISC-RM. After controlling for significant potential confounders verbal IQ (P |
| doi_str_mv | 10.1006/enrs.2000.4106 |
| format | Article |
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Two populations chronically exposed to either high (41 children) or low (39 children) levels of As and Pb were analyzed using the Wechsler Intelligence Scale for Children, Revised Version, for México (WISC-RM). Geometric means of urinary arsenic (AsU) and lead in blood (PbB) were 62.9±0.03 (μgAs/g creatinine) and 8.9±0.03 (μg/dl) for the exposed group and 40.2±0.03 (μgAs/g creatinine) and 9.7±0.02 (μg/dl) for the reference group. The height for age index (HAI) was used as an indicator of chronic malnutrition and sociodemographic information was obtained with a questionnaire. Lead and arsenic were measured by atomic absorption spectrophotometry. Data on full, verbal, and performance intelligence quotients (IQ) scores, long-term memory, linguistic abstraction, attention span, and visuospatial organization were obtained through the WISC-RM. After controlling for significant potential confounders verbal IQ (P<0.01) decreased with increasing concentrations of AsU. The HAI correlated positively with full-scale and performance IQ (P<0.01). Higher levels of AsU were significantly related to poorer performance on WISC-RM factors examining long-term memory and linguistic abstraction, while lower scores in WISC-RM factors measuring attention were obtained at increasing values of PbB. Our results suggest that exposure to As and chronic malnutrition could have an influence on verbal abilities and long-term memory, while Pb exposure could affect the attention process even at low levels.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1006/enrs.2000.4106</identifier><identifier>PMID: 11161656</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>arsenic ; Arsenic - adverse effects ; attention ; Biological and medical sciences ; Child ; Child Development ; Cognition Disorders - chemically induced ; Cross-Sectional Studies ; Developmental Disabilities - chemically induced ; Environmental Exposure ; Environmental Pollutants - adverse effects ; Environmental pollutants toxicology ; Female ; General aspects ; Humans ; Intelligence Tests ; lead ; Lead - adverse effects ; Male ; malnutrition ; Medical sciences ; Memory ; Mexico ; neuropsychological development ; Nutrition Disorders - complications ; Toxicology</subject><ispartof>Environmental research, 2001-02, Vol.85 (2), p.69-76</ispartof><rights>2001 Academic Press</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-9cd6357dae11f386804839a235f0722a49dbfb82d71e3ec1158092190cd269033</citedby><cites>FETCH-LOGICAL-c465t-9cd6357dae11f386804839a235f0722a49dbfb82d71e3ec1158092190cd269033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0013935100941069$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=894301$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11161656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calderón, J.</creatorcontrib><creatorcontrib>Navarro, M.E.</creatorcontrib><creatorcontrib>Jimenez-Capdeville, M.E.</creatorcontrib><creatorcontrib>Santos-Diaz, M.A.</creatorcontrib><creatorcontrib>Golden, A.</creatorcontrib><creatorcontrib>Rodriguez-Leyva, I.</creatorcontrib><creatorcontrib>Borja-Aburto, V.</creatorcontrib><creatorcontrib>Dı́az-Barriga, F.</creatorcontrib><title>Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children. Two populations chronically exposed to either high (41 children) or low (39 children) levels of As and Pb were analyzed using the Wechsler Intelligence Scale for Children, Revised Version, for México (WISC-RM). Geometric means of urinary arsenic (AsU) and lead in blood (PbB) were 62.9±0.03 (μgAs/g creatinine) and 8.9±0.03 (μg/dl) for the exposed group and 40.2±0.03 (μgAs/g creatinine) and 9.7±0.02 (μg/dl) for the reference group. The height for age index (HAI) was used as an indicator of chronic malnutrition and sociodemographic information was obtained with a questionnaire. Lead and arsenic were measured by atomic absorption spectrophotometry. Data on full, verbal, and performance intelligence quotients (IQ) scores, long-term memory, linguistic abstraction, attention span, and visuospatial organization were obtained through the WISC-RM. After controlling for significant potential confounders verbal IQ (P<0.01) decreased with increasing concentrations of AsU. The HAI correlated positively with full-scale and performance IQ (P<0.01). Higher levels of AsU were significantly related to poorer performance on WISC-RM factors examining long-term memory and linguistic abstraction, while lower scores in WISC-RM factors measuring attention were obtained at increasing values of PbB. Our results suggest that exposure to As and chronic malnutrition could have an influence on verbal abilities and long-term memory, while Pb exposure could affect the attention process even at low levels.</description><subject>arsenic</subject><subject>Arsenic - adverse effects</subject><subject>attention</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Development</subject><subject>Cognition Disorders - chemically induced</subject><subject>Cross-Sectional Studies</subject><subject>Developmental Disabilities - chemically induced</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Intelligence Tests</subject><subject>lead</subject><subject>Lead - adverse effects</subject><subject>Male</subject><subject>malnutrition</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Mexico</subject><subject>neuropsychological development</subject><subject>Nutrition Disorders - complications</subject><subject>Toxicology</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotttrxxRJCRuWWbixGsfq6UfSAscoGfLa0-oUdYOdlK1_56ku4JT1dN4rMevXj1m7B3CCgHEJwopryoAWNUI4hVbIChRgmr4a7YAQF4q3uAJO83597Riw-EtO0FEgaIRC_bj8qGPeUxUDLG4SJmCt4UJrtiScU-HbzSm2OdHexe7-Mtb0xWf6Z662O8pDIUPxVd6mK5DsbnznUsUztib1nSZzo9zyW6vLn9ubsrt9-svm4ttaWvRDKWyTvBm7QwhtlwKCbXkylS8aWFdVaZWbtfuZOXWSJzs1F2CqlCBdZVQwPmSfTzk9in-GSkPeu-zpa4zgeKYNUrAdS3ky2DdCJD1nLg6gDbFnBO1uk9-b9KjRtCzbz371rNvPfueHrw_Jo-7Pbn_-FHwBHw4AiZP6tpkgvX5HydVzadPWjJ5oGjSde8p6Ww9BUvOJ7KDdtE_1-AvXBuaIA</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Calderón, J.</creator><creator>Navarro, M.E.</creator><creator>Jimenez-Capdeville, M.E.</creator><creator>Santos-Diaz, M.A.</creator><creator>Golden, A.</creator><creator>Rodriguez-Leyva, I.</creator><creator>Borja-Aburto, V.</creator><creator>Dı́az-Barriga, F.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>20010201</creationdate><title>Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children</title><author>Calderón, J. ; Navarro, M.E. ; Jimenez-Capdeville, M.E. ; Santos-Diaz, M.A. ; Golden, A. ; Rodriguez-Leyva, I. ; Borja-Aburto, V. ; Dı́az-Barriga, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9cd6357dae11f386804839a235f0722a49dbfb82d71e3ec1158092190cd269033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>arsenic</topic><topic>Arsenic - adverse effects</topic><topic>attention</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Development</topic><topic>Cognition Disorders - chemically induced</topic><topic>Cross-Sectional Studies</topic><topic>Developmental Disabilities - chemically induced</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Intelligence Tests</topic><topic>lead</topic><topic>Lead - adverse effects</topic><topic>Male</topic><topic>malnutrition</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Mexico</topic><topic>neuropsychological development</topic><topic>Nutrition Disorders - complications</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calderón, J.</creatorcontrib><creatorcontrib>Navarro, M.E.</creatorcontrib><creatorcontrib>Jimenez-Capdeville, M.E.</creatorcontrib><creatorcontrib>Santos-Diaz, M.A.</creatorcontrib><creatorcontrib>Golden, A.</creatorcontrib><creatorcontrib>Rodriguez-Leyva, I.</creatorcontrib><creatorcontrib>Borja-Aburto, V.</creatorcontrib><creatorcontrib>Dı́az-Barriga, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calderón, J.</au><au>Navarro, M.E.</au><au>Jimenez-Capdeville, M.E.</au><au>Santos-Diaz, M.A.</au><au>Golden, A.</au><au>Rodriguez-Leyva, I.</au><au>Borja-Aburto, V.</au><au>Dı́az-Barriga, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>85</volume><issue>2</issue><spage>69</spage><epage>76</epage><pages>69-76</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children. Two populations chronically exposed to either high (41 children) or low (39 children) levels of As and Pb were analyzed using the Wechsler Intelligence Scale for Children, Revised Version, for México (WISC-RM). Geometric means of urinary arsenic (AsU) and lead in blood (PbB) were 62.9±0.03 (μgAs/g creatinine) and 8.9±0.03 (μg/dl) for the exposed group and 40.2±0.03 (μgAs/g creatinine) and 9.7±0.02 (μg/dl) for the reference group. The height for age index (HAI) was used as an indicator of chronic malnutrition and sociodemographic information was obtained with a questionnaire. Lead and arsenic were measured by atomic absorption spectrophotometry. Data on full, verbal, and performance intelligence quotients (IQ) scores, long-term memory, linguistic abstraction, attention span, and visuospatial organization were obtained through the WISC-RM. After controlling for significant potential confounders verbal IQ (P<0.01) decreased with increasing concentrations of AsU. The HAI correlated positively with full-scale and performance IQ (P<0.01). Higher levels of AsU were significantly related to poorer performance on WISC-RM factors examining long-term memory and linguistic abstraction, while lower scores in WISC-RM factors measuring attention were obtained at increasing values of PbB. Our results suggest that exposure to As and chronic malnutrition could have an influence on verbal abilities and long-term memory, while Pb exposure could affect the attention process even at low levels.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11161656</pmid><doi>10.1006/enrs.2000.4106</doi><tpages>8</tpages></addata></record> |
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| subjects | arsenic Arsenic - adverse effects attention Biological and medical sciences Child Child Development Cognition Disorders - chemically induced Cross-Sectional Studies Developmental Disabilities - chemically induced Environmental Exposure Environmental Pollutants - adverse effects Environmental pollutants toxicology Female General aspects Humans Intelligence Tests lead Lead - adverse effects Male malnutrition Medical sciences Memory Mexico neuropsychological development Nutrition Disorders - complications Toxicology |
| title | Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children |
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