Dopamine depletion impairs precursor cell proliferation in Parkinson disease

Cerebral dopamine depletion is the hallmark of Parkinson disease. Because dopamine modulates ontogenetic neurogenesis, depletion of dopamine might affect neural precursors in the subependymal zone and subgranular zone of the adult brain. Here we provide ultrastructural evidence showing that highly p...

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Veröffentlicht in:	Nature neuroscience 2004-07, Vol.7 (7), p.726-735
Hauptverfasser:	Höglinger, Günter U, Rizk, Pamela, Muriel, Marie P, Duyckaerts, Charles, Oertel, Wolfgang H, Caille, Isabelle, Hirsch, Etienne C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Antiparkinson Agents - therapeutic use Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell Differentiation Cell Division - drug effects Cell proliferation Cells, Cultured Diagnosis Dopamine Dopamine - deficiency Dopamine - physiology Dopamine Antagonists - pharmacology Drug Interactions Ependyma - cytology Ependyma - physiology Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL Neural Cell Adhesion Molecule L1 - metabolism Neurobiology Neurons - metabolism Neurons - pathology Neurons - ultrastructure Neurosciences Olfactory Bulb - cytology Olfactory Bulb - metabolism Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Physiological aspects Rats Rats, Sprague-Dawley Risk factors Rodentia Tubulin - metabolism
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