Oxidative stress and apoptosis in metal ion-induced carcinogenesis
Epidemiological evidence suggests that exposure to certain metals causes carcinogenesis. The mechanisms of metal-induced carcinogenesis have been pursued in chemical, biochemical, cellular, and animal models. Significant evidence has accumulated that oxidative stress may be a common pathway in cellu...
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| Veröffentlicht in: | Free Radical Biology and Medicine 2004-09, Vol.37 (5), p.582-593 |
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| container_title | Free Radical Biology and Medicine |
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| creator | Shi, Honglian Hudson, Laurie G. Liu, Ke Jian |
| description | Epidemiological evidence suggests that exposure to certain metals causes carcinogenesis. The mechanisms of metal-induced carcinogenesis have been pursued in chemical, biochemical, cellular, and animal models. Significant evidence has accumulated that oxidative stress may be a common pathway in cellular responses to exposure to different metals. For example, in the last few years evidence in support of a correlation between the generation of reactive oxygen species, DNA damage, tumor promotion, and arsenic exposure has strengthened. This article summarizes the current literature on metal-mediated oxidative stress, apoptosis, and their relation to metal-mediated carcinogenesis, concentrating on arsenic and chromium. |
| doi_str_mv | 10.1016/j.freeradbiomed.2004.03.012 |
| format | Article |
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| ispartof | Free Radical Biology and Medicine, 2004-09, Vol.37 (5), p.582-593 |
| issn | 0891-5849 1873-4596 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Apoptosis Arsenic Carcinogenesis Carcinogens Chromium Humans Metals - toxicity Neoplasms - chemically induced Neoplasms - pathology Oxidative Stress Signal transduction |
| title | Oxidative stress and apoptosis in metal ion-induced carcinogenesis |
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