MiR-330-5p regulates tyrosinase and PDIA3 expression and suppresses cell proliferation and invasion in cutaneous malignant melanoma

Abstract Background Increasing evidences has suggested that miR-330-5p can function as a tumor suppressor in different types of cancers. However, the effects and the underlying mechanisms of miR-330-5p in the development of cutaneous malignant melanoma (CMM) remain largely unknown. The aim of the pr...

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Veröffentlicht in:	The Journal of surgical research 2016-06, Vol.203 (2), p.434-440
Hauptverfasser:	Su, Bei-bei, Zhou, Shu-wei, Gan, Cai-bin, Zhang, Xiao-ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cell Line Cell Movement Cell Proliferation - genetics Cutaneous malignant melanoma Down-Regulation Function Gene Expression Regulation, Neoplastic Humans Melanoma - genetics Melanoma - metabolism Melanoma - pathology Melanoma, Cutaneous Malignant MicroRNAs - metabolism miR-330-5p Monophenol Monooxygenase - metabolism Neoplasm Invasiveness PDIA3 Protein Disulfide-Isomerases - metabolism Real-Time Polymerase Chain Reaction Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Surgery TYR Up-Regulation
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