Artesunate attenuates glioma proliferation, migration and invasion by affecting cellular mechanical properties

Glioma is one of the most common malignant brain tumors. Current chemotherapy is far from providing satisfactory clinical outcomes for patients with glioma. More efficient drugs are urgently needed. Artesunate (ART) is clinically used as an anti-malarial agent and exhibits potent antiproliferative a...

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Veröffentlicht in:	Oncology reports 2016-08, Vol.36 (2), p.984-990
Hauptverfasser:	Lian, Shizhong, Shi, Ruyi, Huang, Xun, Hu, Xiaoling, Song, Bin, Bai, Yinshan, Yang, Bin, Dong, Jinyao, Du, Zhijie, Zhang, Yanyan, Jia, Junmei, Ma, Ning, Guo, Geng, Wang, Mingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology antitumor effect Apoptosis Apoptosis - drug effects Apoptosis - genetics Artemisinins - pharmacology artesunate biomechanical properties Biomechanics Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer Cancer therapies Care and treatment Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Chemotherapy Claudin-1 - genetics Cytoskeleton Flow cytometry gene claudin-1 Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Glioma Glioma - drug therapy Glioma - genetics Glioma - pathology Gliomas Health aspects Humans Innovations Mechanical properties Medical prognosis Microscopy Morphology Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Plant products Polymerase chain reaction Proteins RNA, Small Interfering - genetics Signal Transduction - drug effects Signal Transduction - genetics Studies Up-Regulation - drug effects Up-Regulation - genetics
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