Clinical application of different sedation regimen in patients with septic shock
To evaluated the 3 sedation regimen for patients with septic shock. The randomized controlled trial wan conducted. Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly. The basic characteristics of patients, the duratio...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2016-06, Vol.96 (22), p.1758-1761 |
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| container_title | Zhong hua yi xue za zhi |
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| creator | Guo, F Wang, Q Yan, C Y Huang, H Y Yu, X Tu, L Y |
| description | To evaluated the 3 sedation regimen for patients with septic shock.
The randomized controlled trial wan conducted. Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly. The basic characteristics of patients, the duration of mechanical ventilation, the length of stay in the ICU, the death rate for 28 days and the regulatory cell (Treg) in peripheral blood were observed. The control group for Treg test was consisted of 20 healthy volunteers.
There were no significant differences between the groups in the death rate for 28 days and the duration of mechanical ventilation. The length of stay in the ICU in dexmedetomidine group was shorter than that in midazolam group(15.21±5.55 vs.19.67±5.7 days, P |
| doi_str_mv | 10.3760/cma.j.issn.0376-2491.2016.22.010 |
| format | Article |
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The randomized controlled trial wan conducted. Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly. The basic characteristics of patients, the duration of mechanical ventilation, the length of stay in the ICU, the death rate for 28 days and the regulatory cell (Treg) in peripheral blood were observed. The control group for Treg test was consisted of 20 healthy volunteers.
There were no significant differences between the groups in the death rate for 28 days and the duration of mechanical ventilation. The length of stay in the ICU in dexmedetomidine group was shorter than that in midazolam group(15.21±5.55 vs.19.67±5.7 days, P<0.05). The Treg of 3 groups was higher than that of control group (11.82±4.93 vs.3.69±1.71, 11.30±3.42 vs. 3.69±1.71, 12.83±6.17 vs. 3.69±1.71) at the first day of ICU. The Treg after 3 ICU days in dexmedetomidine group and the Treg after 5</description><identifier>ISSN: 0376-2491</identifier><identifier>DOI: 10.3760/cma.j.issn.0376-2491.2016.22.010</identifier><identifier>PMID: 27356644</identifier><language>chi</language><publisher>China</publisher><subject>Anesthesia ; Conscious Sedation ; Dexmedetomidine - adverse effects ; Dexmedetomidine - therapeutic use ; Female ; Humans ; Hypnotics and Sedatives - adverse effects ; Hypnotics and Sedatives - therapeutic use ; Intensive Care Units ; Length of Stay ; Male ; Midazolam - adverse effects ; Midazolam - therapeutic use ; Propofol - adverse effects ; Propofol - therapeutic use ; Respiration, Artificial ; Shock, Septic - drug therapy ; Time Factors ; Treatment Outcome</subject><ispartof>Zhong hua yi xue za zhi, 2016-06, Vol.96 (22), p.1758-1761</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27356644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, F</creatorcontrib><creatorcontrib>Wang, Q</creatorcontrib><creatorcontrib>Yan, C Y</creatorcontrib><creatorcontrib>Huang, H Y</creatorcontrib><creatorcontrib>Yu, X</creatorcontrib><creatorcontrib>Tu, L Y</creatorcontrib><title>Clinical application of different sedation regimen in patients with septic shock</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To evaluated the 3 sedation regimen for patients with septic shock.
The randomized controlled trial wan conducted. Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly. The basic characteristics of patients, the duration of mechanical ventilation, the length of stay in the ICU, the death rate for 28 days and the regulatory cell (Treg) in peripheral blood were observed. The control group for Treg test was consisted of 20 healthy volunteers.
There were no significant differences between the groups in the death rate for 28 days and the duration of mechanical ventilation. The length of stay in the ICU in dexmedetomidine group was shorter than that in midazolam group(15.21±5.55 vs.19.67±5.7 days, P<0.05). The Treg of 3 groups was higher than that of control group (11.82±4.93 vs.3.69±1.71, 11.30±3.42 vs. 3.69±1.71, 12.83±6.17 vs. 3.69±1.71) at the first day of ICU. The Treg after 3 ICU days in dexmedetomidine group and the Treg after 5</description><subject>Anesthesia</subject><subject>Conscious Sedation</subject><subject>Dexmedetomidine - adverse effects</subject><subject>Dexmedetomidine - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Intensive Care Units</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Midazolam - adverse effects</subject><subject>Midazolam - therapeutic use</subject><subject>Propofol - adverse effects</subject><subject>Propofol - therapeutic use</subject><subject>Respiration, Artificial</subject><subject>Shock, Septic - drug therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURT2AaFX6F5DHLgl-tms7I6r4qFQJBpgj136hhsQJcSrEv8dSC9O7OvfoDo-QFbBSaMVuXWfLjzKkFEuWQcFlBSVnoErOSwbsgsz_-YwsUwp7JrWoOONwRWZci7VSUs7Jy6YNMTjbUjsMbQ5T6CPtG-pD0-CIcaIJ_YmO-B46jDREOmSSu0S_w3TIxjAFR9Ohd5_X5LKxbcLl-S7I28P96-ap2D0_bjd3u2KASk2FBGhsZbTTWnLPrVBOeYcS3NpJA8IIz1HJtUEOLsvWKNTGV4DGW2gqsSCr0-4w9l9HTFPdheSwbW3E_phqMAykAFPprN6c1eO-Q18PY-js-FP_fUH8AuDzYoA</recordid><startdate>20160614</startdate><enddate>20160614</enddate><creator>Guo, F</creator><creator>Wang, Q</creator><creator>Yan, C Y</creator><creator>Huang, H Y</creator><creator>Yu, X</creator><creator>Tu, L Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20160614</creationdate><title>Clinical application of different sedation regimen in patients with septic shock</title><author>Guo, F ; Wang, Q ; Yan, C Y ; Huang, H Y ; Yu, X ; Tu, L Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-411fa987c7742d2a36c6dce41c5c481383d2e6458e21c411a86e78d91e8da1f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2016</creationdate><topic>Anesthesia</topic><topic>Conscious Sedation</topic><topic>Dexmedetomidine - adverse effects</topic><topic>Dexmedetomidine - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Intensive Care Units</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Midazolam - adverse effects</topic><topic>Midazolam - therapeutic use</topic><topic>Propofol - adverse effects</topic><topic>Propofol - therapeutic use</topic><topic>Respiration, Artificial</topic><topic>Shock, Septic - drug therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Guo, F</creatorcontrib><creatorcontrib>Wang, Q</creatorcontrib><creatorcontrib>Yan, C Y</creatorcontrib><creatorcontrib>Huang, H Y</creatorcontrib><creatorcontrib>Yu, X</creatorcontrib><creatorcontrib>Tu, L Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, F</au><au>Wang, Q</au><au>Yan, C Y</au><au>Huang, H Y</au><au>Yu, X</au><au>Tu, L Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical application of different sedation regimen in patients with septic shock</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2016-06-14</date><risdate>2016</risdate><volume>96</volume><issue>22</issue><spage>1758</spage><epage>1761</epage><pages>1758-1761</pages><issn>0376-2491</issn><abstract>To evaluated the 3 sedation regimen for patients with septic shock.
The randomized controlled trial wan conducted. Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly. The basic characteristics of patients, the duration of mechanical ventilation, the length of stay in the ICU, the death rate for 28 days and the regulatory cell (Treg) in peripheral blood were observed. The control group for Treg test was consisted of 20 healthy volunteers.
There were no significant differences between the groups in the death rate for 28 days and the duration of mechanical ventilation. The length of stay in the ICU in dexmedetomidine group was shorter than that in midazolam group(15.21±5.55 vs.19.67±5.7 days, P<0.05). The Treg of 3 groups was higher than that of control group (11.82±4.93 vs.3.69±1.71, 11.30±3.42 vs. 3.69±1.71, 12.83±6.17 vs. 3.69±1.71) at the first day of ICU. The Treg after 3 ICU days in dexmedetomidine group and the Treg after 5</abstract><cop>China</cop><pmid>27356644</pmid><doi>10.3760/cma.j.issn.0376-2491.2016.22.010</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anesthesia Conscious Sedation Dexmedetomidine - adverse effects Dexmedetomidine - therapeutic use Female Humans Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - therapeutic use Intensive Care Units Length of Stay Male Midazolam - adverse effects Midazolam - therapeutic use Propofol - adverse effects Propofol - therapeutic use Respiration, Artificial Shock, Septic - drug therapy Time Factors Treatment Outcome |
| title | Clinical application of different sedation regimen in patients with septic shock |
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