Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats
The health impact of dust events from China has become a concern within China and in its neighboring countries. Previous epidemiological studies have demonstrated an association between particulate matter exposure and cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to exami...
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| Veröffentlicht in: | Environmental research 2004-05, Vol.95 (1), p.71-76 |
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| creator | Lei, Yu-Chen Chan, Chang-Chuan Wang, Peng-Yau Lee, Chung-Te Cheng, Tsun-Jen |
| description | The health impact of dust events from China has become a concern within China and in its neighboring countries. Previous epidemiological studies have demonstrated an association between particulate matter exposure and cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to examine inflammation markers in the lung and in peripheral blood after exposure to Asian dust storm particles. Using a nose-only inhalation system, eight pulmonary hypertensive rats were exposed to concentrated ambient particles (CAPs) from an actual Asian dust storm that took place between March 18 and 19, 2002; four control rats were also exposed to room air. Four rats exposed to CAPs of 315.6μg/m3 for 6h were classified as the low-exposure group, and another four rats exposed to CAPs of 684.5μg/m3 for 4.5h were classified as the high-exposure group. The animals were sacrificed 36h after exposure. Inflammation markers in the peripheral blood and in the bronchoalveolar lavage (BAL) were analyzed, and IL-6 in BAL was also determined using ELISA. White blood cell counts in peripheral blood increased with increased CAP exposure levels (P |
| doi_str_mv | 10.1016/S0013-9351(03)00136-1 |
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Previous epidemiological studies have demonstrated an association between particulate matter exposure and cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to examine inflammation markers in the lung and in peripheral blood after exposure to Asian dust storm particles. Using a nose-only inhalation system, eight pulmonary hypertensive rats were exposed to concentrated ambient particles (CAPs) from an actual Asian dust storm that took place between March 18 and 19, 2002; four control rats were also exposed to room air. Four rats exposed to CAPs of 315.6μg/m3 for 6h were classified as the low-exposure group, and another four rats exposed to CAPs of 684.5μg/m3 for 4.5h were classified as the high-exposure group. The animals were sacrificed 36h after exposure. Inflammation markers in the peripheral blood and in the bronchoalveolar lavage (BAL) were analyzed, and IL-6 in BAL was also determined using ELISA. White blood cell counts in peripheral blood increased with increased CAP exposure levels (P<0.001, test for trend). In BAL analysis, total cell numbers and the proportion of neutrophil also increased with increased CAP levels (P<0.001, test for trend for both markers). Positive dose–response relationships between CAP exposure and total protein (P<0.05) and between CAPs and LDH activity (P<0.05) were also observed. Moreover, IL-6 protein in BAL increasing with CAP levels (P<0.05, test for trend) was demonstrated. Our results revealed that exposure to particulate matters during an Asian dust storm could increase lung inflammation and injury in pulmonary hypertensive rats. Further studies are needed to determine the components of dust storm particles that may contribute to the particle toxicity.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/S0013-9351(03)00136-1</identifier><identifier>PMID: 15068932</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Air ; Air Pollutants - analysis ; Air Pollutants - toxicity ; Ambient particles ; Animals ; Biological and medical sciences ; Bronchoalveolar Lavage ; Concentrator ; Dose-Response Relationship, Drug ; Dust - analysis ; Dust storm ; Environmental pollutants toxicology ; Enzyme-Linked Immunosorbent Assay ; Inflammation - blood ; Inflammation - chemically induced ; Inflammation markers ; Interleukin-6 - analysis ; Leukocyte Count ; Male ; Medical sciences ; Particle Size ; Pneumonia - chemically induced ; Pulmonary hypertension ; Rats ; Rats, Sprague-Dawley ; Taiwan ; Toxicology</subject><ispartof>Environmental research, 2004-05, Vol.95 (1), p.71-76</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-b30f715231f1c8dfc519b6613bee1574e890b0714b7bec0e9bd8a2a542d8ba5f3</citedby><cites>FETCH-LOGICAL-c540t-b30f715231f1c8dfc519b6613bee1574e890b0714b7bec0e9bd8a2a542d8ba5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0013-9351(03)00136-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15657710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15068932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Yu-Chen</creatorcontrib><creatorcontrib>Chan, Chang-Chuan</creatorcontrib><creatorcontrib>Wang, Peng-Yau</creatorcontrib><creatorcontrib>Lee, Chung-Te</creatorcontrib><creatorcontrib>Cheng, Tsun-Jen</creatorcontrib><title>Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>The health impact of dust events from China has become a concern within China and in its neighboring countries. Previous epidemiological studies have demonstrated an association between particulate matter exposure and cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to examine inflammation markers in the lung and in peripheral blood after exposure to Asian dust storm particles. Using a nose-only inhalation system, eight pulmonary hypertensive rats were exposed to concentrated ambient particles (CAPs) from an actual Asian dust storm that took place between March 18 and 19, 2002; four control rats were also exposed to room air. Four rats exposed to CAPs of 315.6μg/m3 for 6h were classified as the low-exposure group, and another four rats exposed to CAPs of 684.5μg/m3 for 4.5h were classified as the high-exposure group. The animals were sacrificed 36h after exposure. Inflammation markers in the peripheral blood and in the bronchoalveolar lavage (BAL) were analyzed, and IL-6 in BAL was also determined using ELISA. White blood cell counts in peripheral blood increased with increased CAP exposure levels (P<0.001, test for trend). In BAL analysis, total cell numbers and the proportion of neutrophil also increased with increased CAP levels (P<0.001, test for trend for both markers). Positive dose–response relationships between CAP exposure and total protein (P<0.05) and between CAPs and LDH activity (P<0.05) were also observed. Moreover, IL-6 protein in BAL increasing with CAP levels (P<0.05, test for trend) was demonstrated. Our results revealed that exposure to particulate matters during an Asian dust storm could increase lung inflammation and injury in pulmonary hypertensive rats. Further studies are needed to determine the components of dust storm particles that may contribute to the particle toxicity.</description><subject>Air</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - toxicity</subject><subject>Ambient particles</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage</subject><subject>Concentrator</subject><subject>Dose-Response Relationship, Drug</subject><subject>Dust - analysis</subject><subject>Dust storm</subject><subject>Environmental pollutants toxicology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Inflammation - blood</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation markers</subject><subject>Interleukin-6 - analysis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Particle Size</subject><subject>Pneumonia - chemically induced</subject><subject>Pulmonary hypertension</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Taiwan</subject><subject>Toxicology</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuPFCEUhYnROG3rT9Cw0eii9NI09ViZyWR8JJO4UNfkQl1slIIWqjvp3-Cfln5E3bkiB75zgXMYeyrgtQDRvvkMIGQzSCVegnx1FG0j7rGFgKFtYFDyPlv8Qa7Yo1K-VymUhIfsSiho-0GuFuzXrXNk58KT49fFY-Tjrsyc9hRnvsU8exuonkbuows4TTj7KibMPyiXusm3lP12QxkDNyGlkWMcuckp2k3CsKcUMPOAe_xGJ3wXphQxH_jmUK0zxeL3xDPO5TF74DAUenJZl-zru9svNx-au0_vP95c3zVWrWFujATXCbWSwgnbj84qMZi2FdIQCdWtqR_AQCfWpjNkgQYz9rhCtV6NvUHl5JK9OM_d5vRzR2XWky-WQsBIaVe06AE6qAOXTJ1Bm1MpmZzeZl-_ftAC9LEFfWpBHyPWIPWpBX30PbtcsDMTjX9dl9gr8PwCYLEYXMZoffmHa1XXCajc2zNHNY69p6yL9RQtjT7X1vSY_H-e8hutFacY</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Lei, Yu-Chen</creator><creator>Chan, Chang-Chuan</creator><creator>Wang, Peng-Yau</creator><creator>Lee, Chung-Te</creator><creator>Cheng, Tsun-Jen</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20040501</creationdate><title>Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats</title><author>Lei, Yu-Chen ; Chan, Chang-Chuan ; Wang, Peng-Yau ; Lee, Chung-Te ; Cheng, Tsun-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-b30f715231f1c8dfc519b6613bee1574e890b0714b7bec0e9bd8a2a542d8ba5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Air</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollutants - toxicity</topic><topic>Ambient particles</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage</topic><topic>Concentrator</topic><topic>Dose-Response Relationship, Drug</topic><topic>Dust - analysis</topic><topic>Dust storm</topic><topic>Environmental pollutants toxicology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Inflammation - blood</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation markers</topic><topic>Interleukin-6 - analysis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Particle Size</topic><topic>Pneumonia - chemically induced</topic><topic>Pulmonary hypertension</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Taiwan</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lei, Yu-Chen</creatorcontrib><creatorcontrib>Chan, Chang-Chuan</creatorcontrib><creatorcontrib>Wang, Peng-Yau</creatorcontrib><creatorcontrib>Lee, Chung-Te</creatorcontrib><creatorcontrib>Cheng, Tsun-Jen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lei, Yu-Chen</au><au>Chan, Chang-Chuan</au><au>Wang, Peng-Yau</au><au>Lee, Chung-Te</au><au>Cheng, Tsun-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>95</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>The health impact of dust events from China has become a concern within China and in its neighboring countries. Previous epidemiological studies have demonstrated an association between particulate matter exposure and cardiopulmonary mortality. Here, we use pulmonary hypertensive rat models to examine inflammation markers in the lung and in peripheral blood after exposure to Asian dust storm particles. Using a nose-only inhalation system, eight pulmonary hypertensive rats were exposed to concentrated ambient particles (CAPs) from an actual Asian dust storm that took place between March 18 and 19, 2002; four control rats were also exposed to room air. Four rats exposed to CAPs of 315.6μg/m3 for 6h were classified as the low-exposure group, and another four rats exposed to CAPs of 684.5μg/m3 for 4.5h were classified as the high-exposure group. The animals were sacrificed 36h after exposure. Inflammation markers in the peripheral blood and in the bronchoalveolar lavage (BAL) were analyzed, and IL-6 in BAL was also determined using ELISA. White blood cell counts in peripheral blood increased with increased CAP exposure levels (P<0.001, test for trend). In BAL analysis, total cell numbers and the proportion of neutrophil also increased with increased CAP levels (P<0.001, test for trend for both markers). Positive dose–response relationships between CAP exposure and total protein (P<0.05) and between CAPs and LDH activity (P<0.05) were also observed. Moreover, IL-6 protein in BAL increasing with CAP levels (P<0.05, test for trend) was demonstrated. Our results revealed that exposure to particulate matters during an Asian dust storm could increase lung inflammation and injury in pulmonary hypertensive rats. Further studies are needed to determine the components of dust storm particles that may contribute to the particle toxicity.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>15068932</pmid><doi>10.1016/S0013-9351(03)00136-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Air Air Pollutants - analysis Air Pollutants - toxicity Ambient particles Animals Biological and medical sciences Bronchoalveolar Lavage Concentrator Dose-Response Relationship, Drug Dust - analysis Dust storm Environmental pollutants toxicology Enzyme-Linked Immunosorbent Assay Inflammation - blood Inflammation - chemically induced Inflammation markers Interleukin-6 - analysis Leukocyte Count Male Medical sciences Particle Size Pneumonia - chemically induced Pulmonary hypertension Rats Rats, Sprague-Dawley Taiwan Toxicology |
| title | Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats |
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