In vitro dissolution similarity factor (f2) and in vivo bioequivalence criteria, how and when do they match? Using a BCS class II drug as a simulation example

[Display omitted] The present study examined the agreement between in vitro dissolution f2 similarity and in vivo bioequivalence criteria for BCS class II drugs. Dissolution test profiles were generated using the First-order model with varied dissolution parameters around the standard values of a re...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2015-01, Vol.66, p.163-172
Hauptverfasser:	Xie, Feifan, Ji, Shan, Cheng, Zeneng
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Bioequivalence Chemistry, Pharmaceutical Computer Simulation Dissolution Drug Liberation First-order Models, Biological Models, Chemical Numerical convolution Similarity factor Simulation Therapeutic Equivalency
Online-Zugang:	Volltext
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